Feng Y X, Liu F, Bian D, Hu J
Department of Pharmacology, Xinjiang Medical College, Urumqi, China.
Zhongguo Yao Li Xue Bao. 1994 Sep;15(5):473-6.
Adenosine (Ade) 1.3, 13, 130 mg.kg-1 ip inhibited the ability of peripheral leukocytes and peritoneal macrophages in phagocytosing the Staphylococcus albus with [3H]TdR incorporation in mice, declined the hemolytic ability of plaque-forming cells and the production of antibody in mice immunized by sheep erythrocytes. Ade 13, 130 mg.kg-1 ip decreased the mouse serum muramidase (lysozyme) concentration. Dipyridamole (Dip) 10 mg.kg-1 ip attenuated the effects of Ade 130 mg.kg-1 on humoral immunity reaction, but the nonspecific immunity was not attenuated. These results showed that the uptake of Ade may play an important role in the effects of Ade on humoral immunity reaction. Aminophylline (Ami) 100 mg.kg-1 ip attenuated the effects of Ade 130 mg.kg-1 on hemolytic ability of plaque-forming cells and the ability of peripheral leukocytes in phagocytosing Staphylococcus albus. These results suggested that the effects of Ade on murine humoral and nonspecific immunity reaction were mediated by Ade A2 receptor (A2DR).
腺苷（Ade）腹腔注射剂量为1.3、13、130毫克/千克时，可抑制小鼠外周血白细胞和腹腔巨噬细胞吞噬白色葡萄球菌的能力，并降低[3H]TdR掺入量，还可降低经绵羊红细胞免疫的小鼠中形成空斑细胞的溶血能力及抗体产生。腹腔注射13、130毫克/千克的Ade可降低小鼠血清中的溶菌酶浓度。双嘧达莫（Dip）腹腔注射剂量为10毫克/千克时，可减弱130毫克/千克Ade对体液免疫反应的影响，但对非特异性免疫无减弱作用。这些结果表明，Ade的摄取可能在其对体液免疫反应的影响中起重要作用。氨茶碱（Ami）腹腔注射剂量为100毫克/千克时，可减弱130毫克/千克Ade对形成空斑细胞溶血能力及外周血白细胞吞噬白色葡萄球菌能力的影响。这些结果提示，Ade对小鼠体液免疫和非特异性免疫反应的影响是由Ade A2受体（A2DR）介导的。
