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一种基于N-乙酰葡糖胺基-N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺,并以二甲基二辛基氯化铵和L-脯氨酸锌络合物作为增效剂的佐剂配方。

An adjuvant formulation based on N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with dimethyldioctadecylammonium chloride and zinc-L-proline complex as synergists.

作者信息

Grubhofer N

机构信息

Gerbu-Biotechnik GmbH, Gaiberg, Germany.

出版信息

Immunol Lett. 1995 Jan;44(1):19-24. doi: 10.1016/0165-2478(94)00188-w.

DOI:10.1016/0165-2478(94)00188-w
PMID:7721338
Abstract

The formulation consists of N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine, dimethyldioctadecylammonium chloride and the trace element zinc as an L-proline complex. This ternary synergistic composition shows promise as a new adjuvant.

摘要

该制剂由N-乙酰葡糖胺基-N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺、二甲基二十八烷基氯化铵以及作为L-脯氨酸络合物的微量元素锌组成。这种三元协同组合物有望成为一种新型佐剂。

相似文献

1
An adjuvant formulation based on N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with dimethyldioctadecylammonium chloride and zinc-L-proline complex as synergists.一种基于N-乙酰葡糖胺基-N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺,并以二甲基二辛基氯化铵和L-脯氨酸锌络合物作为增效剂的佐剂配方。
Immunol Lett. 1995 Jan;44(1):19-24. doi: 10.1016/0165-2478(94)00188-w.
2
Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺和N-乙酰葡糖胺基-(β1→4)-N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫调节特性研究
Biomed Sci. 1991;2(6):651-8.
3
Genetic influences on the adjuvanticity of muramyl dipeptide in vivo.体内对胞壁酰二肽佐剂活性的遗传影响。
J Immunol. 1982 Jan;128(1):155-60.
4
Enhancement of serum antibody production in mice by oral administration of lipophilic derivatives of muramylpeptides and bacterial lipopolysaccharides with bovine serum albumin.通过口服给予带有牛血清白蛋白的胞壁酰肽和亲脂性衍生物及细菌脂多糖增强小鼠血清抗体产生
Methods Find Exp Clin Pharmacol. 1986 Jan;8(1):19-26.
5
Adjuvant activity of synthetic 6-O-"mycoloyl"-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds.合成的6-O-“霉菌酰基”-N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺及相关化合物的佐剂活性
Infect Immun. 1978 Jun;20(3):600-7. doi: 10.1128/iai.20.3.600-607.1978.
6
[Preparation and characteristics of monoclonal antibodies to N-acetylglucosaminyl-(beta1-4)-N-acetylmuramoyl-alanyl-D-isoglutamine].[N-乙酰葡糖胺基-(β1-4)-N-乙酰胞壁酰-丙氨酰-D-异谷氨酰胺单克隆抗体的制备及特性]
Bioorg Khim. 1993 May;19(5):555-61.
7
Synthesis and immunoadjuvant activities of 2-acetamido-5-O-acetyl-6-O-acyl-2-deoxy-3-O-[(R)-2-propionyl-L-alanyl-D- isoglutamine]-D-glucofuranoses as potential prodrug forms of 6-O-Acyl Derivatives of N-acetylmuramyl dipeptide.2-乙酰氨基-5-O-乙酰基-6-O-酰基-2-脱氧-3-O-[(R)-2-丙酰基-L-丙氨酰-D-异谷氨酰胺]-D-呋喃葡萄糖作为N-乙酰胞壁酰二肽6-O-酰基衍生物潜在前药形式的合成及免疫佐剂活性
J Med Chem. 1982 Sep;25(9):1028-33. doi: 10.1021/jm00351a005.
8
Higher immunoadjuvant activities of N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetylmuramyl-L-alanyl-D-isoglutamine in comparison with N-acetylmuramyl-L-alanyl-D-isoglutamine.与N-乙酰基-胞壁酰-L-丙氨酰-D-异谷氨酰胺相比,N-乙酰-β-D-葡糖胺基-(1-4)-N-乙酰基胞壁酰-L-丙氨酰-D-异谷氨酰胺具有更高的免疫佐剂活性。
Microbiol Immunol. 1979;23(9):933-6. doi: 10.1111/j.1348-0421.1979.tb02828.x.
9
Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.合成的胞壁酰二肽(MDP)N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫佐剂作用。
Z Immunitatsforsch Immunobiol. 1978 Oct;155(1):87-92.
10
Efficient genetically controlled formation of antibody to a synthetic antigen [poly(LTyr, LGlu)-poly(DLAla)- -poly(LLys)] covalently bound to a synthetic adjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine).高效地通过基因控制形成针对与合成佐剂(N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺)共价结合的合成抗原[聚(L-酪氨酸,L-谷氨酸)-聚(D-丙氨酸)-聚(L-赖氨酸)]的抗体。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4933-7. doi: 10.1073/pnas.77.8.4933.

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