Revicki D A, Wu A W, Murray M I
Medical Technology Assessment Program, Battelle Centers for Public Health Research and Evaluation, Arlington, VA 22201, USA.
Med Care. 1995 Apr;33(4 Suppl):AS173-82.
Psychometric health status scales and health utility scales were compared to measure the impact of changes in clinical status in patients infected with the human immunodeficiency virus (HIV). The data used included the first two waves of a longitudinal study of 160 HIV-infected patients, a population that was 34% women and 65% African American. The Medical Outcome Study-HIV Health Survey (MOS-HIV); sleep, cognitive function, and depression scales; the Sickness Impact Profile Home Management Scale; and questions on HIV-related clinical symptoms were administered. Standard gamble utilities and categorical rating scale preferences were assessed for current health state. The MOS-HIV scale scores of asymptomatic patients were significantly higher than those of symptomatic patients and patients with acquired immune deficiency syndrome. No differences were observed for utilities. Increases in clinical symptoms over 4 months were associated with changes in health perception, pain, physical role function, social function, mental health, depression, energy, cognitive function, and categorical rating scale preferences. The MOS-HIV and other health status measures discriminated between HIV disease stages and were associated with clinical status. Standard gamble utilities did not discriminate among the three groups and were not correlated with clinical status.
对心理测量健康状况量表和健康效用量表进行比较，以衡量感染人类免疫缺陷病毒（HIV）患者临床状况变化的影响。所使用的数据包括对160名HIV感染患者进行的纵向研究的前两波，该人群中34%为女性，65%为非裔美国人。实施了医学结局研究-HIV健康调查（MOS-HIV）、睡眠、认知功能和抑郁量表、疾病影响概况家庭管理量表以及关于HIV相关临床症状的问题。评估了当前健康状态的标准博弈效用和分类评定量表偏好。无症状患者的MOS-HIV量表得分显著高于有症状患者和获得性免疫缺陷综合征患者。效用方面未观察到差异。4个月内临床症状的增加与健康感知、疼痛、身体角色功能、社会功能、心理健康、抑郁、精力、认知功能和分类评定量表偏好的变化相关。MOS-HIV和其他健康状况测量方法能够区分HIV疾病阶段，并与临床状况相关。标准博弈效用在三组之间没有区分，且与临床状况无关。
