Rosa T T, Junqueira Júnior L F, Mangia F J, Veiga J P, Pádua F V
Departamento de Clínica Médica, Faculdade de Ciências da Saúde, Universidade de Brasília, DF, Brasil.
Rev Soc Bras Med Trop. 1995 Jan-Mar;28(1):7-11. doi: 10.1590/s0037-86821995000100002.
The effect of an 8 hour-period of water deprivation on fluid and electrolyte renal excretion was investigated in male Wistar rats infected with the strain São Felipe (12SF) of Trypanosoma cruzi, in comparison with age and sex matched non-infected controls. The median percent reductions in the urinary flow (-40% v-63%) and excretion of sodium (-57% v -79%) were smaller in chagasic than in control rats, respectively. So, chagasic rats excreted more than controls. On the other hand, the median percent decrement in the clearance of creatinine was higher in chagasic (-51%) than in controls (-39%). Thus, chagasic rats showed some disturbed renal hydroelectrolytic responses to water deprivation, expressed by smaller conservation, or higher excretion of water and sodium in association with smaller glomerular filtration rate. This fact denoted an elevation in the fractional excretion of sodium and water.
研究了感染克氏锥虫圣费利佩菌株（12SF）的雄性Wistar大鼠在8小时禁水期对液体和电解质肾排泄的影响，并与年龄和性别匹配的未感染对照进行比较。恰加斯病大鼠的尿流（-40%对-63%）和钠排泄（-57%对-79%）的中位数百分比降低分别比对照大鼠小。因此，恰加斯病大鼠的排泄量比对照大鼠多。另一方面，恰加斯病大鼠（-51%）的肌酐清除率中位数降低百分比高于对照大鼠（-39%）。因此，恰加斯病大鼠对禁水表现出一些紊乱的肾水电解质反应，表现为较少的潴留，或较高的水和钠排泄，同时肾小球滤过率较小。这一事实表明钠和水的分数排泄增加。
