Kovacs K, Horvath E, Ozawa Y, Yamada S, Matushita H
Department of Pathology, St. Michael's Hospital, University of Toronto, Ontario, Canada.
Acta Biol Hung. 1994;45(2-4):275-84.
A 48 year old man presented with hyperparathyroidism and acromegaly. Although pancreatic tumour was not demonstrated, the diagnosis of MEN-1 syndrome was made. The parathyroid adenoma was removed surgically and investigated by histology and transmission electron microscopy and was diagnosed as large clear cell adenoma with extensive deposition of glycogen. Much of the endoplasmic reticulum was present in two special forms: annulate lamellae and the rare rail-like configurations both of which showed continuity with the conventional RER as well as with each other. No obvious correlation was apparent between presence of special RER formations and growth rate or endocrine activity of tumour; they may be regarded as signs of cellular dedifferentiation.
一名48岁男性患者表现为甲状旁腺功能亢进和肢端肥大症。尽管未发现胰腺肿瘤，但仍诊断为MEN-1综合征。手术切除甲状旁腺腺瘤，并进行组织学和透射电子显微镜检查，诊断为大透明细胞腺瘤，伴有大量糖原沉积。内质网大多以两种特殊形式存在：环状片层和罕见的铁轨样结构，二者均与传统粗面内质网相连且相互连通。特殊粗面内质网结构的存在与肿瘤的生长速度或内分泌活性之间无明显相关性；它们可被视为细胞去分化的标志。
