Patel A, Halliday G M, Barnetson R S
Department of Dermatology, University of Sydney, Royal Prince Alfred Hospital, Australia.
J Dermatol Sci. 1995 Jan;9(1):12-9. doi: 10.1016/0923-1811(94)00344-e.
It is currently unknown which arm of the immune system is responsible for regression of tumours. We have studied the T lymphocytes infiltrating a spontaneously regressing murine squamous cell carcinoma during the growth, plateau and regression phases of tumour development. In the plateau phase, where tumour growth is partially controlled by the immune system so that tumour size remains static, there was a considerable influx of CD4+ cells into the tumour. There was also an increase in the number of cells expressing the receptor for interleukin 2 (IL-2R), indicating that these cells were probably activated. The number of CD4+ cells remained high during the regression phase, where immunological destruction exceeded tumour growth. In contrast, CD8+ cells were only present in low numbers, and did not change during growth or regression of the tumours. These results indicate that CD4+ cells are probably responsible for tumour destruction. Thus CD4+ T lymphocytes are able to mediate tumour rejection and should be given more consideration for immunotherapy.
目前尚不清楚免疫系统的哪个分支负责肿瘤的消退。我们研究了在肿瘤发展的生长、平台期和消退期浸润自发消退的小鼠鳞状细胞癌的T淋巴细胞。在平台期，肿瘤生长部分受免疫系统控制，肿瘤大小保持稳定，此时有大量CD4+细胞涌入肿瘤。表达白细胞介素2受体（IL-2R）的细胞数量也增加，表明这些细胞可能被激活。在消退期，免疫破坏超过肿瘤生长，CD4+细胞数量仍然很高。相比之下，CD8+细胞数量很少，在肿瘤生长或消退过程中没有变化。这些结果表明CD4+细胞可能负责肿瘤破坏。因此，CD4+T淋巴细胞能够介导肿瘤排斥，在免疫治疗中应给予更多考虑。
