Ackermann H, Hertrich I, Hehr T
Department of Neurology, University of Tübingen, Germany.
Folia Phoniatr Logop. 1995;47(1):15-23. doi: 10.1159/000266338.
Rapid syllable repetitions require alternating articulatory movements and, thus, provide a test for oral diadochokinesis. The present study performed an acoustic analysis of rapid syllable repetitions in patients suffering from idiopathic Parkinson's disease (n = 17), Huntington's chorea (n = 14), Friedreich's ataxia (n = 9), or from a purely cerebellar syndrome (n = 13). Four parameters were considered: the mean number of syllables per train, the median syllable duration with its variation coefficient, and articulatory imprecision in terms of the percentage of incomplete closures. Apart from a few subjects with minor motor deficits only, in all patients at least one of the four measures of diadochokinesis exceeded the normal range. Accordingly, discriminant analysis revealed a highly significant difference between controls and patients with respect to the considered parameters. Thus, oral diadochokinesis tasks represent a sensitive measure of orofacial motor impairment. Moreover, multivariate analysis showed that Parkinson's disease and Friedreich's ataxia are characterized by a highly specific profile of diadochokinesis performance.
快速音节重复需要交替的发音动作，因此可用于测试口腔轮替运动速率。本研究对患有特发性帕金森病（n = 17）、亨廷顿舞蹈症（n = 14）、弗里德赖希共济失调（n = 9）或单纯小脑综合征（n = 13）的患者的快速音节重复进行了声学分析。研究考虑了四个参数：每组音节的平均数量、音节持续时间中位数及其变异系数，以及根据不完全闭合百分比计算的发音不精确度。除了少数仅有轻微运动缺陷的受试者外，所有患者的四项轮替运动速率指标中至少有一项超出正常范围。因此，判别分析显示，在考虑的参数方面，对照组与患者之间存在高度显著差异。因此，口腔轮替运动任务是口面部运动障碍的一项敏感指标。此外，多变量分析表明，帕金森病和弗里德赖希共济失调具有高度特定的轮替运动速率表现特征。
