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帕金森病语音随时间变化的分析:一项历时性实验语音学研究。

Analyzing changes in parkinsonian speech over time: a diachronic experimental phonetics study.

作者信息

Pettorino Massimo, Maffia Marta

机构信息

Department of Literary, Linguistics and Comparative Studies, University of Naples L'Orientale, Naples, Italy.

出版信息

Front Aging Neurosci. 2024 Mar 12;16:1334198. doi: 10.3389/fnagi.2024.1334198. eCollection 2024.

DOI:10.3389/fnagi.2024.1334198
PMID:38533425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10963411/
Abstract

In this contribution the use of web resources for the longitudinal study of speech rhythm of a 'well-known' person diagnosed with Parkinson's disease, the American actor Alan Alda, is proposed. A corpus of 20 speech samples produced in the period between 1979 and 2021 was collected from the web. A rhythmical analysis was conducted, based on two parameters: the percentage of vocalic portion on the total duration of the utterance (%V) and the VtoV, the mean duration of the interval between two consecutive vowel onset points. The results of this study confirm an early alteration of rhythm in parkinsonian speech, with an abnormal increase of %V, already occurring some years before the clinical diagnosis. The observation of speech rhythm variation can therefore be considered as the basis for the realization of a sustainable and non-invasive procedure in support to early diagnosis of Parkinson's disease.

摘要

本文提出利用网络资源对被诊断患有帕金森病的“知名”人士——美国演员艾伦·阿尔达的言语节奏进行纵向研究。从网络上收集了1979年至2021年期间他所发表的20个语音样本组成的语料库。基于两个参数进行了节奏分析:元音部分在话语总时长中的占比(%V)以及VtoV,即两个连续元音起始点之间间隔的平均时长。本研究结果证实帕金森病患者言语节奏的早期改变,即%V异常增加,这在临床诊断前几年就已出现。因此,言语节奏变化的观察可被视为实现一种可持续且非侵入性程序以辅助帕金森病早期诊断的基础。

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本文引用的文献

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Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease.与新发和现患帕金森病相关的视网膜光学相干断层扫描特征。
Neurology. 2023 Oct 17;101(16):e1581-e1593. doi: 10.1212/WNL.0000000000207727. Epub 2023 Aug 21.
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Application and progress of transcranial substantial ultrasound in Parkinson's disease.经颅实质超声在帕金森病中的应用及进展
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Speech Rhythm Variation in Early-Stage Parkinson's Disease: A Study on Different Speaking Tasks.
早期帕金森病的言语节奏变化:关于不同言语任务的研究
Front Psychol. 2021 Jun 14;12:668291. doi: 10.3389/fpsyg.2021.668291. eCollection 2021.
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PLoS One. 2017 Dec 14;12(12):e0189583. doi: 10.1371/journal.pone.0189583. eCollection 2017.
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Automated analysis of connected speech reveals early biomarkers of Parkinson's disease in patients with rapid eye movement sleep behaviour disorder.自动化的口语分析可在快速眼动睡眠行为障碍患者中发现帕金森病的早期生物标志物。
Sci Rep. 2017 Feb 2;7(1):12. doi: 10.1038/s41598-017-00047-5.
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Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder.特发性快速眼动睡眠行为障碍中运动性言语异常的定量评估
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Automatic Evaluation of Speech Rhythm Instability and Acceleration in Dysarthrias Associated with Basal Ganglia Dysfunction.自动评估与基底神经节功能障碍相关的构音障碍的语音节奏不稳定性和加速。
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