Fessler B J, Boumpas D T
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Rheum Dis Clin North Am. 1995 Feb;21(1):81-98.
Deterioration in the function of major organs in patients with systemic lupus erythematosus may be due to causes directly related to the disease itself or to non-lupus related causes. In patients with rapidly progressive immune-mediated disease, therapy may be initiated with pulse glucocorticoids alone or in combination with pulse cyclophosphamide. For selected patients with aggressive life-threatening disease or patients refractory to treatment, experimental therapies such as plasmapheresis or intravenous immunoglobulin may be used as adjuncts in their management.
系统性红斑狼疮患者主要器官功能的恶化可能是由与疾病本身直接相关的原因或与狼疮无关的原因引起的。对于快速进展的免疫介导疾病患者，治疗可单独使用脉冲糖皮质激素或与脉冲环磷酰胺联合启动。对于选定的患有侵袭性危及生命疾病的患者或对治疗难治的患者，血浆置换或静脉注射免疫球蛋白等实验性疗法可作为其治疗的辅助手段。
