• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Safety of the bolus administration of gentamicin.庆大霉素大剂量注射的安全性。
Antimicrob Agents Chemother. 1976 Apr;9(4):633-8. doi: 10.1128/AAC.9.4.633.
2
Clinical monitoring of the effects of gentamicin by electrocochleography.用电耳蜗图对庆大霉素的作用进行临床监测。
J Laryngol Otol. 1984 Jan;98(1):11-21. doi: 10.1017/s0022215100146110.
3
Gentamicin by intravenous bolus injection.静脉推注庆大霉素。
N Z Med J. 1974 Nov 27;80(528):442-3.
4
Gentamicin administration via peritoneal dialysis fluid: the risk of ototoxicity.通过腹膜透析液给予庆大霉素：耳毒性风险
J Laryngol Otol. 1991 Dec;105(12):999-1001. doi: 10.1017/s0022215100118055.
5
Serum levels of gentamicin and tobramycin after slow intravenous bolus injection.缓慢静脉推注后庆大霉素和妥布霉素的血清水平。
Lancet. 1974 Mar 9;1(7854):378-9. doi: 10.1016/s0140-6736(74)93148-1.
6
Gentamicin vestibulotoxicity.庆大霉素前庭毒性
Otolaryngol Head Neck Surg. 1994 Nov;111(5):571-4. doi: 10.1177/019459989411100506.
7
Gentamicin ototoxicity in continuous ambulatory peritoneal dialysis.
J Laryngol Otol. 1993 Aug;107(8):681-5. doi: 10.1017/s0022215100124132.
8
A follow-up study on the cochlear, vestibular and renal function in children treated with gentamicin in the newborn period.一项关于新生儿期接受庆大霉素治疗的儿童耳蜗、前庭和肾功能的随访研究。
Chemotherapy. 1973;18(3):141-53. doi: 10.1159/000221256.
9
Gentamicin intravenous infusion rate: effect on interstitial fluid concentration.庆大霉素静脉输注速率：对组织间液浓度的影响
Antimicrob Agents Chemother. 1977 Nov;12(5):606-8. doi: 10.1128/AAC.12.5.606.
10
Letter: Serum levels of gentamicin after intravenous bolus injection.信件：静脉推注后庆大霉素的血清水平。
Lancet. 1974 Apr 20;1(7860):730. doi: 10.1016/s0140-6736(74)92929-8.

引用本文的文献

1
Intravenous Push Administration of Antibiotics: Literature and Considerations.抗生素静脉推注给药：文献与考量
Hosp Pharm. 2018 Jun;53(3):157-169. doi: 10.1177/0018578718760257. Epub 2018 Mar 8.
2
The anaesthetist as determinant factor of quality of surgical antimicrobial prophylaxis. A survey in a university hospital.麻醉师作为外科手术抗菌预防质量的决定因素。一项在大学医院开展的调查。
Pharm World Sci. 1997 Apr;19(2):89-92. doi: 10.1023/a:1008691007436.
3
Kill kinetics and regrowth patterns of Pseudomonas aeruginosa exposed to concentration-time profiles of tobramycin simulating in vivo infusion and bolus dosing.暴露于模拟体内输注和大剂量给药的妥布霉素浓度-时间曲线下的铜绿假单胞菌的杀灭动力学和再生长模式。
Antimicrob Agents Chemother. 1996 May;40(5):1321-4. doi: 10.1128/AAC.40.5.1321.
4
Kill kinetics and regrowth patterns of Escherichia coli exposed to gentamicin concentration-time profiles simulating in vivo bolus and infusion dosing.暴露于模拟体内推注和输注给药的庆大霉素浓度-时间曲线下的大肠杆菌的杀灭动力学和再生长模式。
Antimicrob Agents Chemother. 1993 Apr;37(4):914-7. doi: 10.1128/AAC.37.4.914.
5
[Gentamicin concentrations in cerebrospinal fluid of patients with inflamed and uninflamed meninges (author's transl)].[患有炎症性和非炎症性脑膜的患者脑脊液中的庆大霉素浓度（作者译）]
Infection. 1980;8(2):86-9. doi: 10.1007/BF01639153.
6
Gentamicin intravenous infusion rate: effect on interstitial fluid concentration.庆大霉素静脉输注速率：对组织间液浓度的影响
Antimicrob Agents Chemother. 1977 Nov;12(5):606-8. doi: 10.1128/AAC.12.5.606.
7
Netilmicin and gentamicin: comparative pharmacology in humans.奈替米星与庆大霉素：人体中的比较药理学
Antimicrob Agents Chemother. 1977 Apr;11(4):609-14. doi: 10.1128/AAC.11.4.609.
8
Why monitor serum levels of gentamicin?为什么要监测庆大霉素的血清水平？
Clin Pharmacokinet. 1978 May-Jun;3(3):202-15. doi: 10.2165/00003088-197803030-00002.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
R-factor mediated gentamicin resistance: A new enzyme which modifies aminoglycoside antibiotics.R 因子介导的庆大霉素耐药性：一种修饰氨基糖苷类抗生素的新酶。
FEBS Lett. 1971 May 20;14(5):293-296. doi: 10.1016/0014-5793(71)80282-x.
3
Pharmacology of gentamicin in the biliary tract of humans.庆大霉素在人体胆道中的药理学
Antimicrob Agents Chemother. 1973 Nov;4(5):538-41. doi: 10.1128/AAC.4.5.538.
4
The use of gentamicin intravenously.庆大霉素的静脉使用。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1973:Suppl 241:23-9.
5
Reflections on the clinical pharmacology of gentamicin.关于庆大霉素临床药理学的思考
Acta Pathol Microbiol Scand B Microbiol Immunol. 1973:Suppl 241:151-.

庆大霉素大剂量注射的安全性。

Safety of the bolus administration of gentamicin.

作者信息

Mendelson J, Portnoy J, Dick V, Black M

出版信息

Antimicrob Agents Chemother. 1976 Apr;9(4):633-8. doi: 10.1128/AAC.9.4.633.

DOI:10.1128/AAC.9.4.633
PMID:773301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429589/
Abstract

A study was done to assess the safety of gentamicin administration by a bolus method. A total of 63 patients were randomly treated with intravenous gentamicin by bolus administration (3 to 5 min) and by slow infusion (2 h). Serum gentamicin levels were measured. Renal and audiovestibular function were monitored. Pure-tone audiometry was performed at the beginning, on day 3, and at the end of therapy. The study revealed that the bolus administration was safe and nontoxic.

摘要

一项研究旨在评估庆大霉素大剂量推注给药方法的安全性。共有63例患者被随机分为两组，分别接受静脉推注庆大霉素（3至5分钟）和缓慢输注（2小时）治疗。测定血清庆大霉素水平，并监测肾脏和听前庭功能。在治疗开始时、第3天和治疗结束时进行纯音听力测定。研究表明，大剂量推注给药是安全且无毒的。