庆大霉素大剂量注射的安全性。
Safety of the bolus administration of gentamicin.
作者信息
Mendelson J, Portnoy J, Dick V, Black M
出版信息
Antimicrob Agents Chemother. 1976 Apr;9(4):633-8. doi: 10.1128/AAC.9.4.633.
Abstract
A study was done to assess the safety of gentamicin administration by a bolus method. A total of 63 patients were randomly treated with intravenous gentamicin by bolus administration (3 to 5 min) and by slow infusion (2 h). Serum gentamicin levels were measured. Renal and audiovestibular function were monitored. Pure-tone audiometry was performed at the beginning, on day 3, and at the end of therapy. The study revealed that the bolus administration was safe and nontoxic.
摘要
一项研究旨在评估庆大霉素大剂量推注给药方法的安全性。共有63例患者被随机分为两组，分别接受静脉推注庆大霉素（3至5分钟）和缓慢输注（2小时）治疗。测定血清庆大霉素水平，并监测肾脏和听前庭功能。在治疗开始时、第3天和治疗结束时进行纯音听力测定。研究表明，大剂量推注给药是安全且无毒的。
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