暴露于模拟体内输注和大剂量给药的妥布霉素浓度-时间曲线下的铜绿假单胞菌的杀灭动力学和再生长模式。
Kill kinetics and regrowth patterns of Pseudomonas aeruginosa exposed to concentration-time profiles of tobramycin simulating in vivo infusion and bolus dosing.
作者信息
Wood P J, Ioannides-Demos L L, Bastone E B, Spicer W J, McLean A J
机构信息
Department of Clinical Pharmacology, Monash University Department of Microbiology, Prahran, Victoria, Australia.
出版信息
Antimicrob Agents Chemother. 1996 May;40(5):1321-4. doi: 10.1128/AAC.40.5.1321.
Abstract
Pseudomonas aeruginosa ATCC 27853 was exposed to tobramycin concentration-time profiles modelling in vivo bolus and infusion dosing. Dependence of bactericidal and bacteriostatic activity on the initial profile of peak concentration (bolus effect > infusion) and area under the antibiotic concentration-time curve was observed at peak concentration/MIC ratios of 10 or below.
摘要
将铜绿假单胞菌ATCC 27853暴露于妥布霉素浓度-时间曲线模型中，该模型模拟了体内推注和输注给药情况。在峰浓度/最低抑菌浓度比值为10或更低时，观察到杀菌和抑菌活性对峰浓度初始曲线（推注效应>输注）和抗生素浓度-时间曲线下面积的依赖性。
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本文引用的文献
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