Weinreb R N, Shakiba S, Zangwill L
Department of Ophthalmology, University of California, San Diego, La Jolla 92093-0946, USA.
Am J Ophthalmol. 1995 May;119(5):627-36. doi: 10.1016/s0002-9394(14)70221-1.
To determine whether retardation (change in polarization) measurements of healthy subjects and glaucoma patients obtained by using a confocal scanning laser polarimeter correspond to known properties of the nerve fiber layer.
A polarimeter, an optical device used to measure the change in linear polarization of light (retardation), was interfaced with a scanning laser ophthalmoscope to obtain retardation data at 65,536 locations (256 x 256 pixels) in a study of normal subjects and patients with primary open-angle glaucoma. To validate the instrument, we compared our measurements with known properties of the human retinal nerve fiber layer in 105 normal subjects. Additionally, we compared retardation measurements in eyes of 64 normal subjects and 64 age-matched glaucoma patients treated in a referral practice.
In normal eyes, mean (+/- S.D.) peripapillary retardation was highest in the superior and inferior arcuate regions and lowest in the temporal and nasal regions, 12.0 +/- 1.9, 13.1 +/- 2.0, 7.0 +/- 1.8, and 7.0 +/- 1.6 degrees, respectively. Retardation decreased toward the periphery and was lower over blood vessels. In normal eyes, retardation decreased with increasing age in the superior and inferior regions. Mean retardation was statistically significantly higher among normal eyes than glaucoma eyes in the inferior and superior regions but not in the temporal or nasal areas.
Scanning laser polarimetry provides quantitative measurements that correspond to known properties of the retinal nerve fiber layer in normal and glaucomatous eyes.
确定使用共焦扫描激光偏振仪获得的健康受试者和青光眼患者的延迟（偏振变化）测量值是否与神经纤维层的已知特性相符。
在一项针对正常受试者和原发性开角型青光眼患者的研究中，将用于测量光的线性偏振变化（延迟）的偏振仪与扫描激光检眼镜连接，以在65536个位置（256×256像素）获取延迟数据。为验证该仪器，我们将105名正常受试者的测量结果与人类视网膜神经纤维层的已知特性进行了比较。此外，我们还比较了在转诊机构接受治疗的64名正常受试者和64名年龄匹配的青光眼患者眼睛的延迟测量值。
在正常眼中，视乳头周围延迟的平均值（±标准差）在上下弓形区域最高，在颞侧和鼻侧区域最低，分别为12.0±1.9、13.1±2.0、7.0±1.8和7.0±1.6度。延迟向周边降低，并且在血管上方更低。在正常眼中，上下区域的延迟随年龄增加而降低。正常眼的平均延迟在上下区域统计学上显著高于青光眼眼，但在颞侧或鼻侧区域则不然。
扫描激光偏振测量法提供了与正常和青光眼眼中视网膜神经纤维层的已知特性相符的定量测量结果。
