Lee A
School of Microbiology and Immunology, University of New South Wales, Sydney, Australia.
Eur J Gastroenterol Hepatol. 1994 Dec;6 Suppl 1:S67-71.
Long-term infection with Helicobacter pylori and the associated gastritis is now thought to cause a predisposition to gastric cancer through cellular changes resulting from inflammatory damage or because of direct effects of the bacterium. MICE AS MODELS FOR H. PYLORI-ASSOCIATED GASTRIC CANCER: Long-term infection of conventional Swiss mice with either H. felis or H. heilmannii results in atrophic gastritis. Infection of specific pathogen-free Balb/c mice results in the development of lesions similar to H. pylori-associated low-grade B-cell gastric lymphomas.
H. pylori-infected mice appear to be excellent models for the study of tumours induced by this bacterium.
目前认为，幽门螺杆菌的长期感染及相关胃炎会通过炎症损伤导致的细胞变化或该细菌的直接作用，使人易患胃癌。
用猫螺杆菌或海尔曼螺杆菌长期感染普通瑞士小鼠会导致萎缩性胃炎。感染无特定病原体的Balb/c小鼠会引发与幽门螺杆菌相关的低度B细胞胃淋巴瘤相似的病变。
幽门螺杆菌感染的小鼠似乎是研究该细菌诱发肿瘤的优秀模型。
