Miller B L, Moats R A, Shonk T, Ernst T, Woolley S, Ross B D
Department of Magnetic Resonance Spectroscopy, Huntington Medical Research Institutes, Pasadena, CA 91105.
Radiology. 1993 May;187(2):433-7. doi: 10.1148/radiology.187.2.8475286.
To define altered metabolites in the brain of patients with probable Alzheimer disease (AD) of two brain regions, localized in vivo hydrogen-1 magnetic resonance (MR) spectroscopy was performed with a short echo time (30 msec) in 11 elderly patients and 10 healthy age-matched subjects. The patients had mild to moderate dementia, assessed with standard neuropsychological tests. Two abnormalities in the patients' cerebral cortex were defined: When compared with healthy subjects, the patients showed a 22% increase (P = .005) (approximately equal to 1.5 mmol/kg) in myo-inositol (MI) and an 11% decrease (P = .005) in residues of N-acetyl (NA), a putative neuronal marker. The elevation of MI in patients with mild to moderate AD suggests that abnormalities in the inositol polyphosphate messenger pathway occur early in the natural history of AD. The combination of high MI and low NA at examination with H-1 MR spectroscopy shows promise as an early diagnostic test for AD.
为了确定两个脑区的可能阿尔茨海默病（AD）患者大脑中代谢物的改变情况，对11名老年患者和10名年龄匹配的健康受试者进行了短回波时间（30毫秒）的活体局部氢-1磁共振（MR）波谱分析。这些患者患有轻度至中度痴呆，通过标准神经心理学测试进行评估。确定了患者大脑皮层的两个异常情况：与健康受试者相比，患者的肌醇（MI）增加了22%（P = 0.005）（约等于1.5 mmol/kg），而作为假定神经元标志物的N-乙酰基（NA）残基减少了11%（P = 0.005）。轻度至中度AD患者中MI的升高表明肌醇多磷酸信使通路的异常在AD自然病程早期就已出现。H-1 MR波谱检查时高MI和低NA的组合有望作为AD的早期诊断测试。
