ATP和去甲肾上腺素的释放介导绵羊肠系膜淋巴管中的兴奋性神经传递。
Mediation of excitatory neurotransmission by the release of ATP and noradrenaline in sheep mesenteric lymphatic vessels.
作者信息
Hollywood M A, McHale N G
机构信息
Department of Physiology, School of Biomedical Science, Queen's University of Belfast, UK.
出版信息
J Physiol. 1994 Dec 1;481 ( Pt 2)(Pt 2):415-23. doi: 10.1113/jphysiol.1994.sp020450.
Abstract
- Spontaneous isometric contractions were measured in rings of sheep mesenteric lymphatics. Field stimulation at short pulse widths increased the frequency of spontaneous contractions and this response was blocked by 3 x 10(-7) M omega-conotoxin and by 10(-6) M guanethidine. 2. Rings that had been incubated with [3H]noradrenaline release 3H in response to field stimulation in a frequency-dependent manner. 3. Exogenous ATP mimicked the response to field stimulation and this was blocked by 10(-4) M suramin but not by prior desensitization with 10(-6) M alpha, beta-methylene ATP. Exogenous noradrenaline was not blocked by 10(-4) M suramin. 4. The excitatory response to field stimulation was not blocked by 10(-4) M suramin but a combination of 10(-4) M suramin and 3 x 10(-6) M phentolamine did block the response. 5. In rings taken from sheep that had been pretreated with reserpine, 10(-4) M suramin alone blocked the response to field stimulation. 6. The results of this study suggest that the excitatory response to stimulation of intramural nerves in sheep mesenteric lymphatics is mediated by the release of both ATP and noradrenaline.
摘要
- 在绵羊肠系膜淋巴管环中测量自发等长收缩。短脉冲宽度的场刺激增加了自发收缩的频率，这种反应被3×10⁻⁷M的ω-芋螺毒素和10⁻⁶M的胍乙啶阻断。2. 用[³H]去甲肾上腺素孵育的环以频率依赖的方式对场刺激释放³H。3. 外源性ATP模拟了对场刺激的反应，这被10⁻⁴M的苏拉明阻断，但不被10⁻⁶M的α,β-亚甲基ATP预先脱敏所阻断。外源性去甲肾上腺素不被10⁻⁴M的苏拉明阻断。4. 对场刺激的兴奋性反应不被10⁻⁴M的苏拉明阻断，但10⁻⁴M的苏拉明和3×10⁻⁶M的酚妥拉明联合使用确实阻断了该反应。5. 在取自用利血平预处理过的绵羊的环中，单独使用10⁻⁴M的苏拉明阻断了对场刺激的反应。6. 本研究结果表明，绵羊肠系膜淋巴管壁内神经刺激的兴奋性反应是由ATP和去甲肾上腺素的释放介导的。
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