Bauer H C, Wedin R
Department of Orthopedics, Karolinska Hospital, Stockholm, Sweden.
Acta Orthop Scand. 1995 Apr;66(2):143-6. doi: 10.3109/17453679508995508.
We assessed the survival after surgery in 153 patients with extremity metastases and 88 with spinal metastases. The survival rate for the whole series of 241 patients was 0.30 at 1 year, 0.15 at 2, and 0.08 at 3 years. The 1-year survival rate was the same for the extremity metastases group and the spinal group. Univariate analysis showed that 1-year survival was related to metastatic load, site of primary tumor, and presence of pathologic fracture. Multivariate regression analysis showed that pathologic fracture, visceral or brain metastases, and lung cancer were negative prognostic variables. Solitary skeletal metastases, breast and kidney cancer, myeloma, and lymphoma were positive variables. A prognostication model based on these variables stratified the patients into 3 groups with a 1-year survival ranging from 0.5 to 0.0. These prognostic variables can be used for differentiating the treatment of cancer patients with pathologic fracture or epidural compression.
我们评估了153例肢体转移瘤患者和88例脊柱转移瘤患者术后的生存率。241例患者的整个系列1年生存率为0.30，2年为0.15，3年为0.08。肢体转移瘤组和脊柱转移瘤组的1年生存率相同。单因素分析显示，1年生存率与转移负荷、原发肿瘤部位及病理性骨折的存在有关。多因素回归分析显示，病理性骨折、内脏或脑转移以及肺癌是负性预后变量。孤立性骨转移、乳腺癌和肾癌、骨髓瘤和淋巴瘤是正性变量。基于这些变量的预后模型将患者分为3组，1年生存率在0.5至0.0之间。这些预后变量可用于区分患有病理性骨折或硬膜外压迫的癌症患者的治疗。
