Ellis S J
Oxford University, Radcliffe Infirmary, Oxford.
Br J Clin Pract. 1995 Jan-Feb;49(1):49-50.
Rapid correction of severe chronic hyponatraemia with hypertonic saline can cause central pontine myelinolysis. Less well appreciated are the dangers of rapid correction with isotonic saline. A case is reported in which correction of severe hyponatraemia by 11 mmol/l in 24 hours with isotonic saline produced extensive extrapontine myelinolysis, one of the manifestations of the osmotic demyelination syndrome.
用高渗盐水快速纠正严重慢性低钠血症可导致中枢性桥脑脱髓鞘病变。等渗盐水快速纠正的危险性则较少受到重视。本文报告一例，用等渗盐水在24小时内将严重低钠血症纠正11 mmol/L，结果产生了广泛的脑桥外脱髓鞘病变，这是渗透性脱髓鞘综合征的表现之一。
