BMJ. 1995 Apr 29;310(6987):1099-104.
To determine the effectiveness of health checks, performed by nurses in primary care, in reducing risk factors for cardiovascular disease and cancer.
Randomised controlled trial.
Five urban general practices in Bedfordshire.
2205 men and women who were randomly allocated a first health check in 1989-90 and a re-examination in 1992-3 (the intervention group); 1916 men and women who were randomly allocated an initial health check in 1992-3 (the control group). All subjects were aged 35-64 at recruitment in 1989.
Serum total cholesterol concentration, blood pressure, body mass index, and smoking prevalence (with biochemical validation of cessation); self reported dietary, exercise, and alcohol habits.
Mean serum total cholesterol was 3.1% lower in the intervention group than controls (difference 0.19 mmol/l (95% confidence interval 0.12 to 0.26)); in women it was 4.5% lower (P < 0.0001) and in men 1.6% (P < 0.05), a significant difference between the sexes (P < 0.01). Self reported saturated fat intake was also significantly lower in the intervention group. Systolic and diastolic blood pressures and body mass index were respectively 1.9%, 1.9%, and 1.4% lower in the intervention group (P < 0.005 in all cases). There was a 3.9% (2.4 to 5.3) difference in the percentage of subjects with a cholesterol concentration > or = 8 mmol/l, but no significant differences in the number with diastolic blood pressure > or = 100 mm Hg or body mass index > or = 30 kg/m2. There was no significant difference between the two groups in prevalence of smoking or excessive alcohol use. Annual rechecks were no more effective than a single recheck at three years, but health checks led to a significant increase in visits to the nurse according to patients' degree of cardiovascular risk.
The benefits of health checks were sustained over three years. The main effects were to promote dietary change and reduce cholesterol concentrations; small differences in blood pressure may have been attributable to accommodation to measurement. The benefits of systematic health promotion in primary care are real, but must be weighed against the costs in relation to other priorities.
确定基层医疗中护士进行的健康检查在降低心血管疾病和癌症风险因素方面的有效性。
随机对照试验。
贝德福德郡的五家城市全科诊所。
2205名男性和女性,他们在1989 - 1990年被随机分配接受首次健康检查,并于1992 - 1993年接受复查(干预组);1916名男性和女性,他们在1992 - 1993年被随机分配接受初次健康检查(对照组)。所有研究对象在1989年招募时年龄为35 - 64岁。
血清总胆固醇浓度、血压、体重指数和吸烟率(戒烟经生化验证);自我报告的饮食、运动和饮酒习惯。
干预组的平均血清总胆固醇比对照组低3.1%(差异为0.19 mmol/l(95%置信区间0.12至0.26));女性低4.5%(P < 0.0001),男性低1.6%(P < 0.05),性别间差异有统计学意义(P < 0.01)。干预组自我报告的饱和脂肪摄入量也显著更低。干预组的收缩压、舒张压和体重指数分别低1.9%、1.9%和1.4%(所有情况P < 0.005)。胆固醇浓度≥8 mmol/l的受试者百分比有3.9%(2.4至5.3)的差异,但舒张压≥100 mmHg或体重指数≥30 kg/m²的人数无显著差异。两组在吸烟或过度饮酒患病率方面无显著差异。年度复查并不比三年一次的单次复查更有效,但根据患者心血管风险程度,健康检查导致看护士的次数显著增加。
健康检查的益处持续了三年。主要作用是促进饮食改变和降低胆固醇浓度;血压的微小差异可能归因于对测量的适应。基层医疗中系统健康促进的益处是真实的,但必须与相对于其他优先事项的成本相权衡。