Aukrust P, Liabakk N B, Müller F, Espevik T, Frøland S S
Medical Dept. A, University of Oslo, National Hospital, Rikshospitalet, Norway.
Infection. 1995 Jan-Feb;23(1):9-15. doi: 10.1007/BF01710050.
The relationships between serum levels of soluble tumor necrosis factor receptors (sTNFRs) and other prognostic and immunological parameters in different immunological subgroups of 64 HIV-1 infected patients were studied. In the patient group as a whole, the raised serum levels of sTNFRs were significantly inversely correlated to the numbers of CD4+ and CD8+ lymphocytes and significantly positively correlated with serum levels of neopterin, HIV-1 p24 antigen and the soluble CD8/CD8+ lymphocyte ratio. However, when the patients were classified into three separate immunological subgroups according to the numbers of CD4+ lymphocytes, only serum levels of neopterin were significantly correlated to levels of sTNFRs in all the defined immunological subgroups. These results indicate that HIV-1 infection is associated with a persistent and chronic immune activation in the TNF system manifested by raised serum levels of sTNFRs, which may reflect sustained activation of the immune system particularly in monocytes/macrophages. Further, these results confirm that, when comparing immunological and virological parameters in HIV-1 infection, different results may be obtained in different immunological subgroups of patients.
对64例HIV-1感染患者不同免疫亚组中血清可溶性肿瘤坏死因子受体（sTNFRs）水平与其他预后及免疫参数之间的关系进行了研究。在整个患者组中，sTNFRs血清水平升高与CD4+和CD8+淋巴细胞数量显著负相关，与新蝶呤、HIV-1 p24抗原血清水平及可溶性CD8/CD8+淋巴细胞比值显著正相关。然而，根据CD4+淋巴细胞数量将患者分为三个不同的免疫亚组时，仅在所有定义的免疫亚组中，新蝶呤血清水平与sTNFRs水平显著相关。这些结果表明，HIV-1感染与TNF系统中持续的慢性免疫激活有关，表现为sTNFRs血清水平升高，这可能反映了免疫系统尤其是单核细胞/巨噬细胞的持续激活。此外，这些结果证实，在比较HIV-1感染中的免疫和病毒学参数时，不同免疫亚组的患者可能会得到不同的结果。
