Karlsen N R, Frøland S S, Reinvang I
Department of Behavioural and Psychosomatic Medicine, Rikshospitalet, National Hospital, Oslo, Norway.
Scand J Psychol. 1994 Sep;35(3):230-9. doi: 10.1111/j.1467-9450.1994.tb00947.x.
The relationship between neuropsychological test performance and immunological parameters was studied in 52 HIV-positive patients within different stages of the infection. All subjects were neuropsychologically tested, the CD4+ and CD8+ lymphocyte count were measured in peripheral blood, and the concentration of neopterin and HIV-p24 antigen were measured in serum. Ten patients with AIDS were defined as neuropsychologically impaired. The CD8+ cell count was the only immunological parameter that could significantly discriminate between AIDS patients with and without neuropsychological impairment. For the total group, significant positive correlations were found between neuropsychological test results and the number of CD8+ and CD4+ lymphocytes, and significant negative correlations were observed between serum concentration of neopterin and neurocognitive function. Regression analyses showed that up to 51% of the variance in test performance could be explained by CD8+ cells and neopterin concentration. The possible role of CD8+ lymphocytes and neopterin in the pathogenesis of HIV-related CNS-dysfunction is discussed.
对52名处于感染不同阶段的HIV阳性患者的神经心理测试表现与免疫参数之间的关系进行了研究。所有受试者均接受了神经心理测试，检测了外周血中CD4 +和CD8 +淋巴细胞计数，并测定了血清中新蝶呤和HIV-p24抗原的浓度。10名艾滋病患者被定义为神经心理受损。CD8 +细胞计数是唯一能够显著区分有和没有神经心理损伤的艾滋病患者的免疫参数。对于整个研究组，神经心理测试结果与CD8 +和CD4 +淋巴细胞数量之间存在显著正相关，血清新蝶呤浓度与神经认知功能之间存在显著负相关。回归分析表明，高达51%的测试表现差异可由CD8 +细胞和新蝶呤浓度解释。讨论了CD8 +淋巴细胞和新蝶呤在HIV相关中枢神经系统功能障碍发病机制中的可能作用。
