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The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity.猴疱疹病毒的补体控制蛋白同源物通过抑制C3转化酶活性来调节血清补体。
J Virol. 1995 Jun;69(6):3889-92. doi: 10.1128/JVI.69.6.3889-3892.1995.
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本文引用的文献

1
Inhibition of complement-mediated cytolysis by the terminal complement inhibitor of herpesvirus saimiri.疱疹病毒萨氏巨细胞病毒的末端补体抑制剂对补体介导的细胞溶解的抑制作用。
J Virol. 1994 Feb;68(2):730-7. doi: 10.1128/JVI.68.2.730-737.1994.
2
Genomic sequencing.基因组测序
Proc Natl Acad Sci U S A. 1984 Apr;81(7):1991-5. doi: 10.1073/pnas.81.7.1991.
3
Isolation and characterization of monoclonal antibodies to structural and nonstructural herpesvirus saimiri proteins.疱疹病毒萨米利结构和非结构蛋白单克隆抗体的分离与鉴定
J Virol. 1984 Dec;52(3):872-83. doi: 10.1128/JVI.52.3.872-883.1984.
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Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system.人补体系统经典途径调节蛋白C4b结合蛋白编码cDNA的分子克隆与特性分析
Biochem J. 1985 Aug 15;230(1):133-41. doi: 10.1042/bj2300133.
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Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins.痘苗病毒编码一种在结构上与补体调控蛋白相关的分泌性多肽。
Nature. 1988 Sep 8;335(6186):176-8. doi: 10.1038/335176a0.
6
Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.人膜辅因子蛋白（MCP）的分子克隆与染色体定位。纳入补体调节蛋白多基因家族的证据。
J Exp Med. 1988 Jul 1;168(1):181-94. doi: 10.1084/jem.168.1.181.
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Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.人C3b/C4b受体（CR1）。由C3/C4结合蛋白特征性的短共有重复序列组成的长同源重复结构域的证实。
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Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes.
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Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.编码人补体衰变加速因子完整序列的cDNA的克隆与特性分析
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Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins.
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猴疱疹病毒的补体控制蛋白同源物通过抑制C3转化酶活性来调节血清补体。

The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity.

作者信息

Fodor W L, Rollins S A, Bianco-Caron S, Rother R P, Guilmette E R, Burton W V, Albrecht J C, Fleckenstein B, Squinto S P

机构信息

Alexion Pharmaceuticals Inc., New Haven, Connecticut 06511, USA.

出版信息

J Virol. 1995 Jun;69(6):3889-92. doi: 10.1128/JVI.69.6.3889-3892.1995.

DOI:10.1128/JVI.69.6.3889-3892.1995
PMID:7745740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189111/
Abstract

The herpesvirus saimiri genome encodes a complement control protein homolog (CCPH). Stable mammalian cell transfectants expressing a recombinant transmembrane form of CCPH (mCCPH) or a 5'FLAG epitope-tagged mCCPH (5'FLAGmCCPH) conferred resistance to complement-mediated cell damage by inhibiting the lytic activity of human serum complement. The function of CCPH was further defined by showing that the mCCPH and the 5'FLAGmCCPH transfectants inhibited C3 convertase activity and effectively reduced cell surface deposition of the activated complement component, C3d.

摘要

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