Smith R W, Egger P, Coggon D, Cawley M I, Cooper C
Department of Rheumatology, Royal Naval Hospital, Haslar, United Kingdom.
Ann Rheum Dis. 1995 Mar;54(3):179-81. doi: 10.1136/ard.54.3.179.
To investigate the suggestion that osteoarthritis (OA) of the hip joint is often caused by subclinical acetabular dysplasia among elderly British women.
We examined 393 hip joints from the radiographs of a sample of women aged 60-75 years undergoing intravenous urography. Acetabular dysplasia was assessed using measurements of the centre-edge (CE) angle and acetabular depth (AD), which are both reduced in this condition. OA was assessed using an overall grade based on the Kellgren and Lawrence system and by measurement of minimum joint space (MJS).
MJS was the more repeatable measure of OA, and showed a strong correlation with overall grade (Spearman rank correlation coefficient rs = -0.61, p < 0.01). MJS was significantly negatively correlated with CE angle (Pearson correlation coefficient r = -0.25, p < 0.001) and AD (r = -0.11, p < 0.05). Consistent with these findings, there was a weak but significant positive correlation between overall grade of OA and one of the two measures (CE angle) of acetabular dysplasia.
These results do not support the hypothesis that mild degrees of acetabular dysplasia account for a substantial proportion of hip OA in elderly women. Changes in hip joint geometry as a result of OA may be responsible for the weak negative association observed.
调查关于英国老年女性髋关节骨关节炎(OA)常由亚临床髋臼发育不良引起的这一观点。
我们对393个髋关节进行了检查,这些髋关节来自年龄在60 - 75岁接受静脉尿路造影的女性样本的X光片。髋臼发育不良通过测量中心边缘(CE)角和髋臼深度(AD)来评估,在这种情况下这两个指标都会降低。OA通过基于凯尔格伦和劳伦斯系统的总体分级以及最小关节间隙(MJS)的测量来评估。
MJS是OA更具重复性的测量指标,并且与总体分级显示出强相关性(斯皮尔曼等级相关系数rs = -0.61,p < 0.01)。MJS与CE角(皮尔逊相关系数r = -0.25,p < 0.001)和AD(r = -0.11,p < 0.05)显著负相关。与这些发现一致,OA的总体分级与髋臼发育不良的两个测量指标之一(CE角)之间存在弱但显著的正相关。
这些结果不支持轻度髋臼发育不良占老年女性髋关节OA很大比例这一假设。OA导致的髋关节几何形状变化可能是观察到的这种弱负相关的原因。