Gallara R V, Bellavia S L
Cátedras de Química Biológica, Facultad de Odontología, UniversidadNacional de Córdoba, Argentina.
Arch Oral Biol. 1995 Jan;40(1):73-7. doi: 10.1016/0003-9969(94)00137-z.
Rats exposed for 2, 5, 10, 20, 35 and 50 days to constant light (CL) showed beta-adrenergic desensitization of the submandibular gland as indicated by dose-response curves to 1.5, 2.0, 3.0, 10.0, 30.0 and 50.0 micrograms/kg isoproterenol. The phenomenon, evident with 1.5, 2.0 and 50.0 micrograms/kg after 2 days at CL, was more intense as time of exposure increased to reach values of about 50% those for controls after 20 days. After 35 and 50 days, desensitization showed some reversion, but the secretory responses were still lower than for controls maintained under a typical photoperiod. In the groups of rats exposed to CL for 20 days, gland wet and dry weights were higher (10%) than those of controls. These changes probably indicate an adaptation of the sympathetic control of salivary secretion induced by environmental illumination.
将大鼠持续暴露于光照（CL）2、5、10、20、35和50天，通过对1.5、2.0、3.0、10.0、30.0和50.0微克/千克异丙肾上腺素的剂量反应曲线表明，下颌下腺出现了β-肾上腺素能脱敏现象。在持续光照2天后，1.5、2.0和50.0微克/千克剂量时出现的这种现象，随着暴露时间的增加而更加明显，在20天后达到约为对照组50%的值。在35天和50天后，脱敏表现出一些恢复，但分泌反应仍低于在典型光周期下维持的对照组。在持续光照20天的大鼠组中，腺体的湿重和干重比对照组高（10%）。这些变化可能表明环境光照诱导了唾液分泌的交感神经控制的适应性变化。
