Sullivan W, Theurkauf W E
Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064, USA.
Curr Opin Cell Biol. 1995 Feb;7(1):18-22. doi: 10.1016/0955-0674(95)80040-9.
Drosophila embryogenesis begins with thirteen mitotic divisions that occur without cytokinesis. During these syncytial divisions, a series of stereotyped nuclear movements produce a syncytial blastoderm embryo that is characterized by a uniform monolayer of cortical nuclei. Inhibitor studies indicate that actin filaments and microtubules mediate the coordinated nuclear movements of the syncytial stages of embryogenesis. Recent genetic and cytological analyses provide new insight into the functions of specific microtubule and actin filament arrays in organizing the syncytial embryo, and these may lead to the identification of novel regulatory and structural components of the cytoskeleton.
果蝇胚胎发育始于十三次无胞质分裂的有丝分裂。在这些合胞体分裂过程中，一系列模式化的核运动产生了一个合胞体囊胚胚胎，其特征是皮层核形成均匀的单层。抑制剂研究表明，肌动蛋白丝和微管介导胚胎发育合胞体阶段的核运动协调。最近的遗传和细胞学分析为特定微管和肌动蛋白丝阵列在合胞体胚胎组织中的功能提供了新的见解，这些可能会导致鉴定细胞骨架的新型调节和结构成分。
