Schmidt M E, Kruesi M J, Elia J, Borcherding B G, Elin R J, Hosseini J M, McFarlin K E, Hamburger S
Section on Clinical Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA.
Psychiatry Res. 1994 Nov;54(2):199-210. doi: 10.1016/0165-1781(94)90007-8.
Levels of calcium in plasma, red blood cells, and mononuclear blood cells, levels of calcium in plasma, and the plasma calcium-to-magnesium ratio were measured at baseline and after 3 weeks of each drug phase of a double-blind, placebo-controlled study of methylphenidate and dextroamphetamine in hyperactive boys. Levels of magnesium in plasma were significantly higher after 3 weeks of dextroamphetamine treatment, and the calcium-to-magnesium ratio was significantly lower after 3 weeks of either drug compared with the baseline or placebo condition. There was no change in magnesium levels in red blood cells or mononuclear blood cells. These measures were obtained 30 minutes before the morning dose and at 9 a.m., 9:30 a.m., 10:30 a.m., 11:00 a.m., and noon on the last day of each 3-week phase. Analysis of variance revealed a drug effect on plasma magnesium and on the calcium-to-magnesium ratio but no drug x time interaction. Although these changes were not correlated with the time course of acute symptomatic response to stimulant therapy, the decrease in the ratio may be relevant to side effects and treatment resistance associated with stimulant use.
在一项针对多动男孩的哌甲酯和右旋苯丙胺双盲、安慰剂对照研究中，于每个药物阶段的基线期及3周后，测量了血浆、红细胞和单核血细胞中的钙水平、血浆钙水平以及血浆钙镁比。右旋苯丙胺治疗3周后，血浆镁水平显著升高，与基线期或安慰剂组相比，两种药物治疗3周后钙镁比均显著降低。红细胞或单核血细胞中的镁水平无变化。这些测量值在每个3周阶段的最后一天于上午服药前30分钟以及上午9点、9:30、10:30、11:00和中午获取。方差分析显示药物对血浆镁和钙镁比有影响，但不存在药物×时间交互作用。尽管这些变化与兴奋剂治疗的急性症状反应时间进程无关，但该比例的降低可能与兴奋剂使用相关的副作用和治疗抵抗有关。
