Carté B K
Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
Curr Opin Biotechnol. 1993 Jun;4(3):275-9. doi: 10.1016/0958-1669(93)90095-e.
Research into marine natural products is evolving from an empirical search for antimicrobial and cytotoxic compounds into a more mechanistic approach to the discovery of enzyme inhibitors and receptor antagonists with therapeutic potential. Several marine natural products have entered pharmaceutical development and others are making significant contributions to our understanding of cellular processes at the biochemical level.
对海洋天然产物的研究正从对抗菌和细胞毒性化合物的经验性探索，转向以更具机制性的方法来发现具有治疗潜力的酶抑制剂和受体拮抗剂。几种海洋天然产物已进入药物研发阶段，其他一些则在生物化学层面上为我们理解细胞过程做出了重大贡献。
