培氏桉培养细胞对（-）-冰片的生物转化

Biotransformation of (-)-borneol by cultured cells of Eucalyptus perriniana.

作者信息

Orihara Y, Furuya T

机构信息

School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

Phytochemistry. 1993 Nov;34(4):1045-8. doi: 10.1016/s0031-9422(00)90710-6.

DOI:10.1016/s0031-9422(00)90710-6

PMID:7764236

Abstract

Six new biotransformation products, (-)-borneol 2-O-beta-gentiobioside, (-)-borneol 2-O-beta-sophoroside, (-)-borneol 2',6'-di-O-(beta-D-glucopyranosyl)-beta-D-glucopyranoside, 6-exo-hydroxyborneol 2-O-beta-D-glucopyranoside, 4-hydroxyborneol 2-O-beta-D-glucopyranoside and 5-exo-hydroxyborneol 2-O-beta-gentiobioside, together with 5-exo-hydroxyborneol 2-O-beta-D-glucopyranoside, were isolated from jar fermentor cultures of Eucalyptus perriniana following administration of (-)-borneol.

摘要

在给予（-）-冰片后，从佩里桉的罐式发酵培养物中分离出六种新的生物转化产物，即（-）-冰片2-O-β-龙胆二糖苷、（-）-冰片2-O-β-槐糖苷、（-）-冰片2′,6′-二-O-（β-D-吡喃葡萄糖基）-β-D-吡喃葡萄糖苷、6-外向羟基冰片2-O-β-D-吡喃葡萄糖苷、4-羟基冰片2-O-β-D-吡喃葡萄糖苷和5-外向羟基冰片2-O-β-龙胆二糖苷，以及5-外向羟基冰片2-O-β-D-吡喃葡萄糖苷。