Woo J T, Ono H, Tsuji T
Sagami Chemical Research Center, Kanagawa, Japan.
Biosci Biotechnol Biochem. 1995 Feb;59(2):350-2. doi: 10.1271/bbb.59.350.
New cysteine protease inhibitors, named cathestatin A and B, have been discovered as metabolites of Penicillium citrinum. Cathestatins were found to be decarbamidoyl analogs of estatins and showed a specific inhibition for cysteine proteases. Cathestatins suppressed parathyroid hormone (PTH)-stimulated 45Ca release in organ cultures of chick embryonic calvaria.
新的半胱氨酸蛋白酶抑制剂，命名为组织蛋白酶抑制素A和B，已被发现是桔青霉的代谢产物。发现组织蛋白酶抑制素是依他汀的脱氨基甲酰类似物，并对半胱氨酸蛋白酶表现出特异性抑制作用。组织蛋白酶抑制素在鸡胚颅骨器官培养物中抑制甲状旁腺激素（PTH）刺激的45Ca释放。
