Berning S E, Madsen L, Iseman M D, Peloquin C A
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.
Am J Respir Crit Care Med. 1995 Jun;151(6):2006-9. doi: 10.1164/ajrccm.151.6.7767552.
Ofloxacin and ciprofloxacin are potentially useful agents for treating mycobacterial infections. We retrospectively reviewed 7 years' experience with these agents in 103 patients. Ofloxacin was used primarily to treat tuberculosis (TB), dosed to achieve 2-hour postdose serum concentrations of 8-12 micrograms/ml. Ciprofloxacin was used primarily to treat Mycobacterium avium complex (MAC) infection, dosed to achieve 2-hour post-dose serum concentrations of 4-6 micrograms/ml. Despite differences in patient characteristics, underlying disease, and concurrent medications, ofloxacin and ciprofloxacin were associated with a similar spectrum and incidence of adverse reactions. Both drugs were generally well tolerated. Adverse effects led to an ofloxacin dosage change in 1 patient (3%) and discontinuation of ofloxacin in 2 patients (6%). Adverse effects led to a ciprofloxacin dosage change in 2 patients (3%) and discontinuation of ciprofloxacin in 5 patients (7%). Ofloxacin and ciprofloxacin appear to be tolerated as well as or better than other "second-line" antimycobacterial drugs.
氧氟沙星和环丙沙星可能是治疗分枝杆菌感染的有效药物。我们回顾性分析了7年间103例患者使用这两种药物的经验。氧氟沙星主要用于治疗结核病（TB），给药剂量以达到给药后2小时血清浓度为8 - 12微克/毫升。环丙沙星主要用于治疗鸟分枝杆菌复合群（MAC）感染，给药剂量以达到给药后2小时血清浓度为4 - 6微克/毫升。尽管患者特征、基础疾病和同时使用的药物存在差异，但氧氟沙星和环丙沙星的不良反应谱和发生率相似。两种药物总体耐受性良好。不良反应导致1例患者（3%）改变氧氟沙星剂量，2例患者（6%）停用氧氟沙星。不良反应导致2例患者（3%）改变环丙沙星剂量，5例患者（7%）停用环丙沙星。氧氟沙星和环丙沙星的耐受性似乎与其他“二线”抗分枝杆菌药物相当或更好。
