Palmer J N, Hartogensis W E, Patten M, Fortuin F D, Long C S
Cardiology Section, San Francisco Veterans Affairs Medical Center, California, USA.
J Clin Invest. 1995 Jun;95(6):2555-64. doi: 10.1172/JCI117956.
Interleukin-1 (IL-1), initially called "endogenous pyrogen," is primarily known as a mediator of inflammation. However, it also plays many other diverse physiologic roles including the stimulation and inhibition of both primary cells in culture and the interstitial and parenchymal cells of a number of organs including the heart. In the heart, IL-1 expression has traditionally been reported in situations where there is immunologic myocardial injury such as occurs during transplant rejection and congestive heart failure. For this reason, all of the effects of IL-1 have been presumed to be deleterious. Using a cell culture model which allows both the muscle cells (myocytes) and nonmuscle cells (fibroblasts) to be evaluated separately, we have found that IL-1 induces both cardiac myocyte hypertrophy and reinitiates myocyte DNA synthesis. In stark contrast, IL-1 exerts a potent anti-proliferative effect on cardiac fibroblasts. To our knowledge this is the first report concerning the differential effects of IL-1 on myocardial cell growth in culture and, given the inducible expression of IL-1 by myocardial cells during stress, underscores the importance of investigating the complex nature of the intracardiac cell-cell interactions that occur in the heart.
白细胞介素-1（IL-1）最初被称为“内源性致热原”，主要作为炎症介质为人所知。然而，它还发挥许多其他不同的生理作用，包括刺激和抑制培养中的原代细胞以及包括心脏在内的许多器官的间质细胞和实质细胞。在心脏中，传统上报道IL-1表达出现在存在免疫性心肌损伤的情况下，例如在移植排斥和充血性心力衰竭期间发生的情况。因此，IL-1的所有作用都被认为是有害的。使用一种细胞培养模型，该模型允许分别评估肌肉细胞（心肌细胞）和非肌肉细胞（成纤维细胞），我们发现IL-1诱导心肌细胞肥大并重新启动心肌细胞DNA合成。与之形成鲜明对比的是，IL-1对心脏成纤维细胞具有强大的抗增殖作用。据我们所知，这是关于IL-1对培养中心肌细胞生长的不同影响的第一份报告，并且鉴于应激期间心肌细胞可诱导表达IL-1，强调了研究心脏中发生的心脏内细胞间相互作用的复杂性质的重要性。
