Ray M B, Desmet V J, Fevery J, De Groote J, Bradburne A F, Desmyter J
J Clin Pathol. 1976 Feb;29(2):89-93. doi: 10.1136/jcp.29.2.89.
Chronic hepatitis was diagnosed on liver biopsy of 76 patients; 52 (68%)had HBsAg. Of the 52 patients with HBsAg, 23% had HBsAg shown by immunofluorescence on the liver, while it could not be detected with radioimmunoassay on the serum; 77% had HBsAg detectable in liver and in serum, and none had HBsAg in serum only. HBsAg was detected more frequently in chronic aggressive hepatitis and active cirrhosis than in chronic persistent hepatitis and cirrhosis with little activity. No correlation was found in the different forms of chronic hepatitis between the HBsAg status on the one hand, and levels of transaminases, gammaglobulins, and auto-antibodies on the other. Acute hepatitis was diagnosed on liver biopsy of 24 patients; 50% had HBsAg. Liver tissue positivity was very low in the fully developed stage compared to serum positivity. In 146 patients with other liver ailments, both liver and serum were negative for HBsAg.
76例患者经肝活检诊断为慢性肝炎；其中52例（68%）HBsAg阳性。在这52例HBsAg阳性患者中，23%的患者肝脏免疫荧光显示有HBsAg，但血清放射免疫测定未检测到；77%的患者肝脏和血清中均可检测到HBsAg，无一例仅血清中可检测到HBsAg。慢性活动性肝炎和活动性肝硬化患者中HBsAg的检出率高于慢性持续性肝炎和低活动性肝硬化患者。在不同类型的慢性肝炎中，一方面HBsAg状态与另一方面转氨酶、γ球蛋白和自身抗体水平之间未发现相关性。24例患者经肝活检诊断为急性肝炎；其中50%HBsAg阳性。与血清阳性相比，在疾病完全发展阶段肝脏组织的阳性率非常低。146例患有其他肝脏疾病的患者，肝脏和血清HBsAg均为阴性。
