抗-HBc阳性献血者中存在常规放射免疫测定法检测不到的HBsAg的血清学证据。
Serological evidence of presence of HBsAg undetectable by conventional radioimmunoassay in anti-HBc positive blood donors.
作者信息
Katchaki J N, Siem T H, Brouwer R
出版信息
J Clin Pathol. 1978 Sep;31(9):837-9. doi: 10.1136/jcp.31.9.837.
Abstract
Sera from two blood donors, one of whom was implicated in a case of post-transfusion hepatitis B, were found to be positive for anti-HBc and negative for HBsAg by conventional radioimmunoassay and were retested for HBsAg after concentration (pepsin digestion and polyethylene glycol precipitation). The presence of occult HBsAg was confirmed in both. These observations have implications for blood transfusion, and wider studies of anti-HBc in blood donors are recommended before the introduction of routine screening for anti-HBc and exclusion of the positive donors from blood donation.
摘要
两名献血者的血清，其中一人涉及一起输血后乙型肝炎病例，通过传统放射免疫测定法检测发现抗 - HBc呈阳性而HBsAg呈阴性，并在浓缩（胃蛋白酶消化和聚乙二醇沉淀）后重新检测HBsAg。两人均证实存在隐匿性HBsAg。这些观察结果对输血有影响，建议在引入抗 - HBc常规筛查并将阳性献血者排除在献血之外之前，对献血者中的抗 - HBc进行更广泛的研究。
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