肝硬化、肝纤维化和肝细胞癌的病因。
Aetiology of cirrhosis, hepatic fibrosis, and hepatocellular carcinoma.
作者信息
Blenkinsopp W K, Haffenden G P
出版信息
J Clin Pathol. 1977 Jun;30(6):579-84. doi: 10.1136/jcp.30.6.579.
Abstract
Histological study of 69 cases of cirrhosis, 9 of severe generalised hepatic fibrosis, and 19 of hepatocellular carcinoma showed an association with alcohol, hepatitis B surface antigen (HBsAg) or a1-antitrypsin bodies in, respectively, 41 (cirrhosis), 5 (fibrosis), and 9 (carcinoma). Eight of the cirrhotic cases and two of the carcinoma cases had double associations, HBsAg being present in all. Torcein and aldehyde fuchsin staining gave both false positive and false negative results when compared with immunofluorescence and immunoperoxidase methods for HBsAg. Large amounts of copper were found in four cirrhotic livers, and moderate amounts in 13: the diagnostic value of copper staining is questioned.
摘要
对69例肝硬化、9例重度广泛性肝纤维化和19例肝细胞癌进行组织学研究，结果显示，酒精、乙肝表面抗原（HBsAg）或α1-抗胰蛋白酶体分别与41例（肝硬化）、5例（纤维化）和9例（癌）相关。8例肝硬化病例和2例癌病例存在双重关联，所有病例均存在HBsAg。与HBsAg的免疫荧光和免疫过氧化物酶方法相比，orcein和醛复红染色出现了假阳性和假阴性结果。在4例肝硬化肝脏中发现大量铜，13例中发现中等量铜：铜染色的诊断价值受到质疑。
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