SWI-SNF复合物：一种染色质重塑机器？
The SWI-SNF complex: a chromatin remodeling machine?
作者信息
Peterson C L, Tamkun J W
机构信息
Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA.
出版信息
Trends Biochem Sci. 1995 Apr;20(4):143-6. doi: 10.1016/s0968-0004(00)88990-2.
PMID:7770913
Abstract
The SWI-SNF complex plays a key role in the regulation of eukaryotic gene expression. Genetic studies in the yeast Saccharomyces cerevisiae suggest that one role for the complex is to antagonize chromatin-mediated repression of transcription. Recent biochemical studies indicate that S. cerevisiae and putative human SWI-SNF complexes use the energy of ATP hydrolysis to disrupt nucleosome structure.
摘要
SWI-SNF复合物在真核基因表达调控中起关键作用。对酿酒酵母的遗传学研究表明，该复合物的一个作用是对抗染色质介导的转录抑制。最近的生化研究表明，酿酒酵母和假定的人类SWI-SNF复合物利用ATP水解的能量来破坏核小体结构。
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