Yokochi T, Inoue Y, Kato Y, Sugiyama T, Jiang G Z, Kawai M, Fukada M, Takahashi K
Department of Microbiology, Aichi Medical University, Japan.
FEMS Immunol Med Microbiol. 1995 Feb;10(3-4):181-4. doi: 10.1111/j.1574-695X.1995.tb00031.x.
Immunization with lipopolysaccharide from Klebsiella O3 as an immunological adjuvant did not cause the death of mice in systemic anaphylaxis to bovine serum albumin. On the other hand, most mice immunized with lipopolysaccharide from Escherichia coli O111, Klebsiella O4 and Salmonella minnesota did die. Klebsiella O3 lipopolysaccharide enhanced IgM and IgG antibody response to BSA more markedly than Escherichia coli O111 lipopolysaccharide, while it affected the production of IgE antibody only slightly. therefore, it is suggested that the inhibition of systemic anaphylaxis by Klebsiella O3 lipopolysaccharide adjuvant might be related to its strong adjuvant action on IgM and IgG class antibody production, and that high levels of circulating IgM and IgG antibodies might act as blocking antibodies in the development of IgE-mediated systemic anaphylaxis.
用肺炎克雷伯菌O3脂多糖作为免疫佐剂进行免疫，不会导致小鼠在对牛血清白蛋白的全身性过敏反应中死亡。另一方面，大多数用大肠杆菌O111、肺炎克雷伯菌O4和明尼苏达沙门氏菌脂多糖免疫的小鼠确实死亡。肺炎克雷伯菌O3脂多糖比大肠杆菌O111脂多糖更显著地增强了对牛血清白蛋白的IgM和IgG抗体反应，而它对IgE抗体产生的影响仅轻微。因此，提示肺炎克雷伯菌O3脂多糖佐剂对全身性过敏反应的抑制作用可能与其对IgM和IgG类抗体产生的强大佐剂作用有关，并且高水平的循环IgM和IgG抗体可能在IgE介导的全身性过敏反应的发生中起封闭抗体的作用。
