Arora K, Dai H, Kazuko S G, Jamal J, O'Connor M B, Letsou A, Warrior R
Department of Molecular Biology and Biochemistry, University of California, Irvine 92717, USA.
Cell. 1995 Jun 2;81(5):781-90. doi: 10.1016/0092-8674(95)90539-1.
Decapentaplegic (dpp), a TGF beta-related ligand, plays a key role in Drosophila development. Although dpp receptors have been isolated, the downstream components of the signaling pathway remain to be identified. We have cloned the schnurri (shn) gene and show that it encodes a putative zinc finger transcription factor homologous to the human major histocompatibility complex-binding proteins 1 and 2. Mutations in shn affect multiple events that require dpp signaling as well as the transcription of dpp-responsive genes. Genetic interactions and the strikingly similar phenotypes of mutations in shn and the dpp receptors encoded by thick veins and punt suggest that shn plays a downstream role in dpp signaling.
Decapentaplegic（dpp）是一种与转化生长因子β相关的配体，在果蝇发育中起关键作用。尽管已分离出dpp受体，但信号通路的下游成分仍有待确定。我们克隆了 schnurri（shn）基因，并表明它编码一种推定的锌指转录因子，与人主要组织相容性复合体结合蛋白1和2同源。shn中的突变影响多个需要dpp信号传导的事件以及dpp反应性基因的转录。shn突变与由thick veins和punt编码的dpp受体突变具有遗传相互作用且表型惊人相似，这表明shn在dpp信号传导中起下游作用。
