钒：药物代谢酶模式的调节剂及其在可移植小鼠淋巴瘤细胞增殖中的关键作用。
Vanadium: a modifier of drug-metabolizing enzyme patterns and its critical role in cellular proliferation in transplantable murine lymphoma.
作者信息
Chakraborty A, Ghosh R, Roy K, Ghosh S, Chowdhury P, Chatterjee M
机构信息
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
出版信息
Oncology. 1995 Jul-Aug;52(4):310-4. doi: 10.1159/000227480.
Vanadium, as ammonium monovanadate, has been found to stimulate tumour cell proliferation in mice bearing a transplantable ascitic lymphoma. Markers including microsomal cytochrome P-450, UDP-glucuronyltransferase and cytosolic glutathione-S-transferase showed substantial alterations in a dose-responsive manner with vanadium administration when compared to the controls. Stimulation of tumour progression is also reflected by increased tumour cell count and decreased survival of the host.
已发现，作为偏钒酸铵的钒可刺激患有可移植性腹水淋巴瘤的小鼠体内肿瘤细胞的增殖。与对照组相比，包括微粒体细胞色素P-450、尿苷二磷酸葡萄糖醛酸基转移酶和胞质谷胱甘肽-S-转移酶在内的标志物，在给予钒后呈现出剂量依赖性的显著变化。肿瘤细胞数量增加和宿主存活率降低也反映出钒对肿瘤进展的促进作用。
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