Perlingeiro R C, Queiroz M L
Department of Pharmacology and Hemocentre, State University of Campinas, UNICAMP, SP, Brazil.
Hum Exp Toxicol. 1995 Mar;14(3):281-6. doi: 10.1177/096032719501400308.
The chemotactic and nitroblue tetrazolium reducing activities of neutrophils from 48 mercury-exposed workers were examined and compared with those of non-exposed, age- and sex-matched individuals. At the time of testing, the exposed population had a mean (+/- s.d.) urinary mercury concentration of 24.0 +/- 20.1 micrograms g-1 creatinine and in 44 of these workers urinary mercury levels were below the accepted threshold level (TLV) of 50 micrograms g-1 creatinine. The two neutrophil functions were significantly reduced in the mercury-exposed workers compared with the controls. In 28 of these workers, chemotaxis was re-evaluated 6 months later. During the intervening 6 months, the level of hygiene was improved throughout the plant and urinary mercury concentrations were determined monthly in each worker. Despite a significant reduction in urinary mercury concentrations, neutrophil migration did not return to within the normal range. These results suggest that 'safe' level mercury exposure may lead to impairment of neutrophil function.
对48名汞接触工人的中性粒细胞趋化活性和硝基蓝四氮唑还原活性进行了检测，并与未接触汞、年龄和性别匹配的个体进行了比较。在测试时，接触汞人群的尿汞平均浓度（±标准差）为24.0±20.1微克/克肌酐，其中44名工人的尿汞水平低于公认的50微克/克肌酐阈值（TLV）。与对照组相比，汞接触工人的这两种中性粒细胞功能显著降低。其中28名工人在6个月后重新评估了趋化性。在这6个月期间，整个工厂的卫生水平得到了改善，并且每月测定每名工人的尿汞浓度。尽管尿汞浓度显著降低，但中性粒细胞迁移并未恢复到正常范围内。这些结果表明，“安全”水平的汞接触可能导致中性粒细胞功能受损。
