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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Priest N D, Newton D, Day J P, Talbot R J, Warner A J

Biomedical Research Department, AEA Technology, Didcot, Oxon, UK.

Hum Exp Toxicol. 1995 Mar;14(3):287-93. doi: 10.1177/096032719501400309.

26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left the blood after 15 min and the decline continued, leaving < 1% in blood after 2 d; the losses occurred both to renal excretion and through uptake by other compartments. Estimated excretion up to 13 d was 83% (urine) and 1.8% (faeces). Whole-body retention of 15% at 13 d declined to approximately 4% at 1178 d, when the daily reduction corresponded to a biological half-life of 7 y, suggesting that sustained intake of dietary aluminium may lead to a progressively increasing internal deposit. 3. The metabolism of 67Ga differed markedly from that of 26Al in all aspects studied.

将26铝和67镓以柠檬酸盐的形式通过静脉注射给予一名健康男性志愿者。通过全身放射性测量研究了两种示踪剂的滞留情况。通过伽马射线能谱法和/或加速器质谱法测定血液和排泄物中的水平。2. 15分钟后，超过一半的26铝已离开血液，且下降仍在继续，2天后血液中残留量<1%；损失既有通过肾脏排泄的，也有被其他组织摄取的。估计13天内的排泄量为83%（尿液）和1.8%（粪便）。13天时全身滞留率为15%，到1178天时降至约4%，此时每日减少量相当于生物半衰期为7年，这表明持续摄入膳食铝可能导致体内沉积物逐渐增加。3. 在所有研究的方面，67镓的代谢与26铝明显不同。

Priest N D, Newton D, Day J P, Talbot R J, Warner A J

Biomedical Research Department, AEA Technology, Didcot, Oxon, UK.

Hum Exp Toxicol. 1995 Mar;14(3):287-93. doi: 10.1177/096032719501400309.

26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left the blood after 15 min and the decline continued, leaving < 1% in blood after 2 d; the losses occurred both to renal excretion and through uptake by other compartments. Estimated excretion up to 13 d was 83% (urine) and 1.8% (faeces). Whole-body retention of 15% at 13 d declined to approximately 4% at 1178 d, when the daily reduction corresponded to a biological half-life of 7 y, suggesting that sustained intake of dietary aluminium may lead to a progressively increasing internal deposit. 3. The metabolism of 67Ga differed markedly from that of 26Al in all aspects studied.

将26铝和67镓以柠檬酸盐的形式通过静脉注射给予一名健康男性志愿者。通过全身放射性测量研究了两种示踪剂的滞留情况。通过伽马射线能谱法和/或加速器质谱法测定血液和排泄物中的水平。2. 15分钟后，超过一半的26铝已离开血液，且下降仍在继续，2天后血液中残留量<1%；损失既有通过肾脏排泄的，也有被其他组织摄取的。估计13天内的排泄量为83%（尿液）和1.8%（粪便）。13天时全身滞留率为15%，到1178天时降至约4%，此时每日减少量相当于生物半衰期为7年，这表明持续摄入膳食铝可能导致体内沉积物逐渐增加。3. 在所有研究的方面，67镓的代谢与26铝明显不同。