D'Avanzo B, La Vecchia C
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Br J Cancer. 1995 Jun;71(6):1359-62. doi: 10.1038/bjc.1995.264.
Risk factors for male breast cancer were investigated in a case-control study of 21 cases and 82 controls admitted to hospital for acute, non-neoplastic, non-hormone-related diseases in the Greater Milan area between 1988 and 1994. More educated men tended to be at higher risk of breast cancer, with a multivariate odds ratio (OR) of 2.6 [95% confidence interval (CI) 0.7-9.4]. The OR was 3.2 (95% CI 1.1-9.6) for those in the higher social class. Men with no offspring were at higher risk than fathers, with an OR of 5.5 (95% CI 1.8-16.7). A history of breast cancer in female relatives was reported by two cases and one control, giving an OR of 8.5 (95% CI 1.1-69.0). Cases were somewhat heavier than controls, and significantly taller, with an OR of 5.7 (95% CI 1.6-19.9) for subjects taller than 170 cm vs shorter ones. The association with weight, however, decreased after allowance for height, and no difference was observed for body mass index. Socioeconomic correlates and family history are similar to well-assessed risk factors for female breast cancer. The associations with anthropometric measures and childlessness may find an explanation in chromosomal abnormalities, such as Klinefelter's syndrome, or other hormone-related disorders.
在一项病例对照研究中，对1988年至1994年间在大米兰地区因急性、非肿瘤性、非激素相关疾病入院的21例男性乳腺癌患者和82例对照者进行了危险因素调查。受教育程度较高的男性患乳腺癌的风险往往更高，多变量优势比（OR）为2.6[95%置信区间（CI）0.7 - 9.4]。社会阶层较高者的OR为3.2（95%CI 1.1 - 9.6）。无子女的男性比有子女的男性风险更高，OR为5.5（95%CI 1.8 - 16.7）。2例病例和1例对照者报告有女性亲属患乳腺癌的病史，OR为8.5（95%CI 1.1 - 69.0）。病例组比对照组稍重，且显著更高，身高超过170cm者与身高较矮者相比，OR为5.7（95%CI 1.6 - 19.9）。然而，在考虑身高因素后，与体重的关联减弱，且身体质量指数未观察到差异。社会经济相关因素和家族史与已充分评估的女性乳腺癌危险因素相似。与人体测量指标和无子女的关联可能可以用染色体异常（如克兰费尔特综合征）或其他激素相关疾病来解释。
