Vaxman F, Olender S, Lambert A, Nisand G, Grenier J F
INSERM U61 et Laboratoire Pautrier, Chirurgie B, Hôpitaux Universitaires de Strasbourg, France.
Eur Surg Res. 1996 Jul-Aug;28(4):306-14. doi: 10.1159/000129471.
The improvement of the wound healing process in humans by vitamin supplements is still controversial because of the lack of a clearly demonstrated correlation with the mechanical properties of scars.
The aim of this work was to study the effects of high doses of ascorbic acid (AA) and pantothenic acid (PA) on the wound healing process of human skin.
Two groups of patients undergoing surgery for tattoo removal by the successive resection procedure received AA (1 or 3 g/day) and PA (0.2 or 0.9 g/day). More than 80 mechanical, biological and histological parameters were investigated in both preoperated skin and the scars.
The breaking energy of scars was higher in group 2, and energy and treatment were directly correlated (p = 0.006). Mg and Mn significantly rose in group 2 whereas Fe decreased in a dose-dependent manner. Intragroup comparison showed patient and treatment effects for Mg, a time.treatment effect for Cu and a treatment effect for Fe.
The degree and rapidity of variations rather than the variations of the absolute values themselves of fibroblasts, hydroxyproline, Fe, Cu and Mg are significantly related to the enhancement of the mechanical properties of scars. From this study, it may be assumed that in order to obtain 'better', more solid and resistant scars, the decrease of Fe must be quick and acute in order to avoid the harmful effects of toxic radicals; the increase of Cu, Mg and Mn must be early and high in order to have more stable and solid collagen.
由于缺乏与瘢痕力学性能的明确相关性，维生素补充剂对人类伤口愈合过程的改善仍存在争议。
本研究旨在探讨高剂量抗坏血酸（AA）和泛酸（PA）对人体皮肤伤口愈合过程的影响。
两组接受连续切除法去除纹身手术的患者分别接受AA（1或3克/天）和PA（0.2或0.9克/天）。对术前皮肤和瘢痕进行了80多项力学、生物学和组织学参数的研究。
第2组瘢痕的断裂能较高，能量与治疗呈直接相关（p = 0.006）。第2组中镁和锰显著升高，而铁呈剂量依赖性降低。组内比较显示镁有患者和治疗效应，铜有时间-治疗效应，铁有治疗效应。
成纤维细胞、羟脯氨酸、铁、铜和镁的变化程度和速度而非绝对值本身的变化与瘢痕力学性能的增强显著相关。从本研究可以推测，为了获得“更好”、更坚实和有抵抗力的瘢痕，铁的降低必须迅速且剧烈，以避免自由基的有害影响；铜、镁和锰的增加必须尽早且大量，以便形成更稳定和坚实的胶原蛋白。
