Bond R, Rose J F, Ellis J W, Lloyd D H
Department of Small Animal Medicine and Surgery, Royal Veterinary College, Hatfield, Hertfordshire.
J Small Anim Pract. 1995 Mar;36(3):99-104. doi: 10.1111/j.1748-5827.1995.tb02840.x.
A randomised-double-blind parallel study compared the clinical and antimicrobial efficacies of a miconazole-chlorhexidine shampoo with a selenium sulphide shampoo for the treatment of seborrhoeic dermatitis associated with Malassezia pachydermatis in 33 basset hounds. All 16 miconazole-chlorhexidine treated hounds and 11 of 17 selenium sulphide treated hounds improved when shampooed at three-day intervals for three weeks. The miconazole-chlorhexidine treated hounds showed significantly greater reductions in pruritus (P < 0.01), erythema (P < 0.001), exudation (P < 0.01) and overall severity (P < 0.001), and in counts of M pachydermatis (P < 0.001), total bacteria (P < 0.001) and coagulase-positive staphylococci (P < 0.001), when compared to the selenium sulphide treated group. Improvements in scaling and coat condition did not vary significantly between the two groups. These results indicate that seborrhoeic dermatitis in basset hounds is often associated with elevated cutaneous populations of M pachydermatis and bacteria, and that the miconazole-chlorhexidine shampoo is more effective than the selenium sulphide product for the treatment for this disease.
一项随机双盲平行研究比较了咪康唑 - 氯己定洗发水和硫化硒洗发水对33只巴吉度猎犬马拉色菌厚皮病相关性脂溢性皮炎的临床和抗菌疗效。所有16只接受咪康唑 - 氯己定治疗的猎犬以及17只接受硫化硒治疗的猎犬中的11只，在每隔三天洗发三周后病情有所改善。与硫化硒治疗组相比，咪康唑 - 氯己定治疗的猎犬在瘙痒（P < 0.01）、红斑（P < 0.001）、渗出（P < 0.01）和总体严重程度（P < 0.001）方面的降低更为显著，在厚皮马拉色菌数量（P < 0.001）、总细菌数量（P < 0.001）和凝固酶阳性葡萄球菌数量（P < 0.001）方面也是如此。两组在脱屑和被毛状况的改善方面没有显著差异。这些结果表明，巴吉度猎犬的脂溢性皮炎通常与皮肤中厚皮马拉色菌和细菌数量增加有关，并且咪康唑 - 氯己定洗发水比硫化硒产品对这种疾病的治疗更有效。
