Maynard L, Rème C A, Viaud S
VIRBAC SA, 06511 Carros, France.
J Small Anim Pract. 2011 Nov;52(11):566-72. doi: 10.1111/j.1748-5827.2011.01124.x. Epub 2011 Oct 10.
Two antimicrobial shampoos for treatment of canine Malassezia dermatitis (CMD) were compared in a prospective, randomised, single-blinded, field clinical trial.
Sixty-seven dogs with pedal or generalised dermatitis associated with Malassezia overgrowth (MO) were treated with 3% chlorhexidine shampoo (3%CHX) or 2% miconazole-2% chlorhexidine shampoo (2%MIC/CHX) and evaluated for up to 6 weeks until cytological recovery. Pruritus, erythema, papules, greasy seborrhoea, scaling, malodour, excoriations, secondary hairloss, lichenification, hyperpigmentation and lesion extent were each scored on a 0-3 severity scale and combined making an aggregate score.
Among 54 dogs with good treatment compliance, reduction of yeast counts by at least 88% was recorded in 21 of 22 dogs with 3%CHX and 30 of 32 dogs with 2%MIC/CHX. No significant difference was detected between products for yeast count reduction (P=0·592). Time to cytological recovery was not significantly different between groups (P=0·960). Lesion score was significantly reduced in both groups after treatment (72·5 ±25·7% with 3%CHX versus 78·7 ±22·3% with 2%MIC/CHX, P=0·309). Four dogs treated with chlorhexidine shampoo showed minor adverse effects.
In this study, 3%CHX was clinically as effective as 2%MIC/CHX for treatment of CMD.
在一项前瞻性、随机、单盲的现场临床试验中，比较两种用于治疗犬马拉色菌性皮炎（CMD）的抗菌洗发水。
67只患有与马拉色菌过度生长（MO）相关的足部或全身性皮炎的犬，分别用3%洗必泰洗发水（3%CHX）或2%咪康唑 - 2%洗必泰洗发水（2%MIC/CHX）进行治疗，并评估长达6周，直至细胞学恢复。瘙痒、红斑、丘疹、油腻性皮脂溢、脱屑、异味、擦伤、继发性脱毛、苔藓化、色素沉着和病变范围均按0 - 3严重程度评分，并合并得出总分。
在54只治疗依从性良好的犬中，22只使用3%CHX的犬中有21只以及32只使用2%MIC/CHX的犬中有30只酵母菌计数减少至少88%。两种产品在减少酵母菌计数方面未检测到显著差异（P = 0·592）。两组之间细胞学恢复时间无显著差异（P = 0·960）。治疗后两组病变评分均显著降低（3%CHX组为72·5 ±25·7%，2%MIC/CHX组为78·7 ±22·3%，P = 0·309）。4只使用洗必泰洗发水治疗的犬出现轻微不良反应。
在本研究中,3%CHX在治疗CMD方面临床效果与2%MIC/CHX相当。
