Echeverria P D, Chang C P, Smith D
J Pediatr. 1976 Jul;89(1):8-10. doi: 10.1016/s0022-3476(76)80917-1.
Forty-two strains of Escherichia coli that agglutinated in pools of antisera used to identify "enteropathogenic" serotypes were tested for heat-labile and heat-stable toxin production and for their ability to invade intestinal mucosa. None of the strains tested were enterotoxigenic or enteroinvasive as determined by the adrenal cell (heat-labile toxin), the suckling mouse (heat-stable toxin), or guinea pig eye (invasive capacity) assays. Our observations suggest that serotyping of E. coli is an unreliable method to identify isolates that are capable of causing gastroenteritis, at least as determined by available in vitro techniques.
对42株在用于鉴定“肠道致病性”血清型的抗血清混合液中发生凝集的大肠杆菌菌株进行了检测，以确定其热不稳定毒素和热稳定毒素的产生情况以及它们侵袭肠黏膜的能力。通过肾上腺细胞（热不稳定毒素）、乳鼠（热稳定毒素）或豚鼠眼（侵袭能力）试验确定，所检测的菌株均无肠毒素产生或无侵袭性。我们的观察结果表明，至少根据现有的体外技术判断，大肠杆菌血清分型是鉴定能够引起胃肠炎的分离株的不可靠方法。
