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一名正在服用口服类固醇和甲氨蝶呤的哮喘患者发生致命性水痘肺炎。

Fatal chickenpox pneumonia in an asthmatic patient on oral steroids and methotrexate.

作者信息

Gatnash A A, Connolly C K

机构信息

Department of Medicine, Memorial Hospital, Darlington, Co Durham, UK.

出版信息

Thorax. 1995 Apr;50(4):422-3. doi: 10.1136/thx.50.4.422.

DOI:10.1136/thx.50.4.422
PMID:7785019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC474301/
Abstract

A 49 year old man with a long history of severe chronic asthma, treated with oral corticosteroids and weekly doses of methotrexate, contracted chickenpox from his son whose chickenpox rash had developed three weeks before presentation. Five days before admission the patient developed a vesicular skin rash which became extensive, with general malaise, bilateral pneumonia, and acute deterioration of his asthma. He died two weeks after admission despite treatment with acyclovir.

摘要

一名49岁男性,有严重慢性哮喘病史,长期口服皮质类固醇并每周服用甲氨蝶呤,因接触三周前出现水痘皮疹的儿子而感染水痘。入院前五天,患者出现水疱性皮疹,皮疹广泛扩散,并伴有全身不适、双侧肺炎和哮喘急性恶化。尽管接受了阿昔洛韦治疗,但患者在入院两周后死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f630/474301/9b3023625c21/thorax00309-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f630/474301/65980b87f35a/thorax00309-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f630/474301/9b3023625c21/thorax00309-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f630/474301/65980b87f35a/thorax00309-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f630/474301/9b3023625c21/thorax00309-0111-a.jpg

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引用本文的文献

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本文引用的文献

1
Chickenpox pneumonia: experience with antiviral treatment.水痘肺炎:抗病毒治疗的经验
Thorax. 1988 Aug;43(8):627-30. doi: 10.1136/thx.43.8.627.
2
Varicella pneumonia in the adult.成人水痘肺炎
N J Med. 1989 Jun;86(6):475-8.
3
Chickenpox pneumonia: an association with pregnancy.水痘肺炎:与妊娠的关联。
Thorax. 1989 Oct;44(10):812-5. doi: 10.1136/thx.44.10.812.
4
Early treatment with acyclovir for varicella pneumonia in otherwise healthy adults: retrospective controlled study and review.阿昔洛韦对健康成年水痘肺炎患者的早期治疗:回顾性对照研究与综述
Rev Infect Dis. 1990 Sep-Oct;12(5):788-98. doi: 10.1093/clinids/12.5.788.
5
Parenteral and oral acyclovir for management of varicella pneumonia in pregnancy: a case report with review of literature.静脉注射和口服阿昔洛韦治疗妊娠期水痘肺炎:1例病例报告并文献复习
W V Med J. 1991 May;87(5):204-6.
6
Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.卡氏肺孢子虫肺炎作为甲氨蝶呤治疗哮喘的并发症。
Thorax. 1991 Dec;46(12):936-7. doi: 10.1136/thx.46.12.936.