Halbreich U, Rojansky N, Palter S, Tworek H, Hissin P, Wang K
Department of Psychiatry, State University of New York at Buffalo, SUNY-AB 14215, USA.
Biol Psychiatry. 1995 Apr 1;37(7):434-41. doi: 10.1016/0006-3223(94)00181-2.
To investigate the influence of estrogen replacement on serotonergic activity in postmenopausal women, the serotonin agonist meta-chlorophenylpiperazine (m-CPP) (0.5 mg/kg) was given orally to 18 normal postmenopausal women, 11 of whom were also tested following 30 days' treatment with estrogen transdermal patches (estraderm 0.1 mg). Fifteen normal, healthy women of reproductive status served as a control group. Cortisol and prolactin responses to m-CPP were measured. Without estrogen, the prolactin and cortisol responses of postmenopausal women to m-CPP were blunted compared to those of reproductive women. Estrogen replacement increased the hormonal responses. It is suggested that decreased serotonergic activity in postmenopausal women might contribute to their vulnerability to affective disorders. Estrogen replacement therapy might decrease this vulnerability and might add to the efficacy of serotonergic antidepressants when warranted.
为研究雌激素替代对绝经后女性血清素能活性的影响，对18名正常绝经后女性口服血清素激动剂间氯苯哌嗪（m-CPP，0.5毫克/千克），其中11名女性在接受30天经皮雌激素贴片（雌二醇0.1毫克）治疗后也进行了测试。15名处于生育期的正常健康女性作为对照组。测量了皮质醇和催乳素对m-CPP的反应。在没有雌激素的情况下，绝经后女性对m-CPP的催乳素和皮质醇反应与处于生育期的女性相比减弱。雌激素替代增加了激素反应。提示绝经后女性血清素能活性降低可能导致她们易患情感障碍。雌激素替代疗法可能会降低这种易感性，并在必要时增强血清素能抗抑郁药的疗效。
