血液系统恶性肿瘤化疗后发生的肠壁囊样积气症：4例报告

Pneumatosis cystoides intestinalis after chemotherapy for hematological malignancies: report of 4 cases.

作者信息

Hashimoto S, Saitoh H, Wada K, Kobayashi T, Furushima H, Kawai H, Shinbo T, Funakoshi K, Takahashi H, Shibata A

机构信息

First Department of Internal Medicine, Niigata University School of Medicine.

出版信息

Intern Med. 1995 Mar;34(3):212-5. doi: 10.2169/internalmedicine.34.212.

DOI:10.2169/internalmedicine.34.212

PMID:7787331

Abstract

Pneumatosis cystoides intestinalis (PCI) is known to be a relatively rare condition which is characterized by gas cysts in the gastrointestinal mucosa. We treated four cases of PCI accompanied by hematological malignancies during chemotherapy treatment. All cases suffered from abdominal discomfort. Abdominal X-ray films revealed gas cysts in the intestine. PCI was observed during leukocytopenic states, and three cases had septicemia. Etoposide was administered to three cases, and prednisolone to all cases. It is considered that PCI sometimes occurs in patients with hematological malignancies during a period of leukocytopenia, and may be caused by intestinal mucosal damage due to myelosuppressive agents and immunosuppression from prednisolone.

摘要

肠气囊肿症（PCI）是一种相对罕见的疾病，其特征是胃肠道黏膜出现气体囊肿。我们治疗了4例在化疗期间并发血液系统恶性肿瘤的PCI患者。所有病例均有腹部不适。腹部X线片显示肠道有气体囊肿。PCI在白细胞减少状态下被观察到，3例患者发生了败血症。3例患者使用了依托泊苷，所有患者均使用了泼尼松龙。据认为，PCI有时会在血液系统恶性肿瘤患者白细胞减少期间发生，可能是由骨髓抑制药物导致的肠道黏膜损伤以及泼尼松龙引起的免疫抑制所致。