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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Timbrell J A, Seabra V, Waterfield C J

Toxicology Department, School of Pharmacy, London, U.K.

Gen Pharmacol. 1995 May;26(3):453-62. doi: 10.1016/0306-3623(94)00203-y.

Taurine is a ubiquitous, free amino acid found in mammalian systems. 2. The biological functions of taurine are unclear. 3. Various in vivo data suggest that taurine has a variety of protective functions and deficiency leads to pathological changes. 4. Depletion in rats of taurine increases susceptibility to liver damage from carbon tetrachloride. 5. Susceptibility to a variety of hepatotoxicants correlates with the estimated hepatic taurine level. 6. In vitro data suggest that taurine can protect cells against toxic damage. 7. Taurine protects isolated hepatocytes against carbon tetrachloride, hydrazine and 1,4-naphthoquinone but not against allyl alcohol, alpha-naphthylisothiocyanate (ANIT) or diaminodiphenyl methane (DAPM) cytotoxicity. 8. The mechanisms of protection are unclear but may include modulation of calcium levels, osmoregulation and membrane stabilization.

牛磺酸是一种在哺乳动物系统中普遍存在的游离氨基酸。2. 牛磺酸的生物学功能尚不清楚。3. 各种体内数据表明，牛磺酸具有多种保护功能，缺乏会导致病理变化。4. 大鼠体内牛磺酸的耗竭会增加对四氯化碳所致肝损伤的易感性。5. 对多种肝毒物的易感性与估计的肝脏牛磺酸水平相关。6. 体外数据表明，牛磺酸可保护细胞免受毒性损伤。7. 牛磺酸可保护分离的肝细胞免受四氯化碳、肼和1,4-萘醌的损伤，但不能抵御烯丙醇、α-萘基异硫氰酸酯（ANIT）或二氨基二苯甲烷（DAPM）的细胞毒性。8. 保护机制尚不清楚，但可能包括调节钙水平、渗透调节和膜稳定作用。

Timbrell J A, Seabra V, Waterfield C J

Toxicology Department, School of Pharmacy, London, U.K.

Gen Pharmacol. 1995 May;26(3):453-62. doi: 10.1016/0306-3623(94)00203-y.

Taurine is a ubiquitous, free amino acid found in mammalian systems. 2. The biological functions of taurine are unclear. 3. Various in vivo data suggest that taurine has a variety of protective functions and deficiency leads to pathological changes. 4. Depletion in rats of taurine increases susceptibility to liver damage from carbon tetrachloride. 5. Susceptibility to a variety of hepatotoxicants correlates with the estimated hepatic taurine level. 6. In vitro data suggest that taurine can protect cells against toxic damage. 7. Taurine protects isolated hepatocytes against carbon tetrachloride, hydrazine and 1,4-naphthoquinone but not against allyl alcohol, alpha-naphthylisothiocyanate (ANIT) or diaminodiphenyl methane (DAPM) cytotoxicity. 8. The mechanisms of protection are unclear but may include modulation of calcium levels, osmoregulation and membrane stabilization.

牛磺酸是一种在哺乳动物系统中普遍存在的游离氨基酸。2. 牛磺酸的生物学功能尚不清楚。3. 各种体内数据表明，牛磺酸具有多种保护功能，缺乏会导致病理变化。4. 大鼠体内牛磺酸的耗竭会增加对四氯化碳所致肝损伤的易感性。5. 对多种肝毒物的易感性与估计的肝脏牛磺酸水平相关。6. 体外数据表明，牛磺酸可保护细胞免受毒性损伤。7. 牛磺酸可保护分离的肝细胞免受四氯化碳、肼和1,4-萘醌的损伤，但不能抵御烯丙醇、α-萘基异硫氰酸酯（ANIT）或二氨基二苯甲烷（DAPM）的细胞毒性。8. 保护机制尚不清楚，但可能包括调节钙水平、渗透调节和膜稳定作用。