Zanotto P M, Gao G F, Gritsun T, Marin M S, Jiang W R, Venugopal K, Reid H W, Gould E A
NERC Institute of Virology and Environmental Microbiology, Oxford, United Kingdom.
Virology. 1995 Jun 20;210(1):152-9. doi: 10.1006/viro.1995.1326.
The mode and tempo of arbovirus evolution and dispersal can help to explain the dynamics of pandemics, viral outbreaks, and emerging viruses. By comparing nucleotide and deduced amino acid sequences of their envelope proteins, we describe the continuous distribution of the tick-borne encephalitis (TBE) complex viruses, the most important flaviviruses in Europe, across major geographical areas and the conditions under which mutations occur. The analyses reveal a correlation between the geographical and genetic distances of these viruses. The arthropod host appears to be a key factor for the formation and maintenance of this cline by constraining TBE dispersal and evolution. This is also illustrated by comparisons with mosquito-borne flaviviruses.
虫媒病毒进化和传播的方式及速度有助于解释大流行、病毒爆发和新出现病毒的动态变化。通过比较蜱传脑炎（TBE）复合病毒包膜蛋白的核苷酸序列和推导的氨基酸序列，我们描述了欧洲最重要的黄病毒——蜱传脑炎复合病毒在主要地理区域的连续分布情况以及发生突变的条件。分析揭示了这些病毒的地理距离与遗传距离之间的相关性。节肢动物宿主似乎是通过限制蜱传脑炎病毒的传播和进化来形成和维持这种渐变群的关键因素。与蚊媒黄病毒的比较也说明了这一点。
