Truong L D, Stewart M G, Hao H, Yutani C, Jordan P H
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Am J Surg. 1995 Jul;170(1):27-32. doi: 10.1016/s0002-9610(99)80247-5.
Lymphoepithelial cyst of the pancreas is a rare but distinctive cystic lesion lined by a mature, keratinizing squamous epithelium and surrounded by lymphoid tissue.
To gain more insights into this entity, we describe 5 examples of lymphoepithelial cyst of the pancreas (2 of which were briefly described before) and compare them with similar cases in the literature for a total of 19 cases.
The male:female ratio was 16:3; patients' ages ranged from 32 to 73 years (mean and median 51). The lymphoepithelial cyst was incidentally found at autopsy in 4 patients (21%) or during evaluation for unrelated diseases in another 4 patients (21%). In the remaining 11 patients, the cyst was associated with abdominal pain in 9 (47% of all patients), nausea/vomiting in 3 (16%), diarrhea in 1 (5%), and nonspecific systemic symptoms in 6 (32%) (some patients had more than 1 associated symptom). Computed axial tomography scan, with or without ultrasonographic study, was done in 16 cases and uniformly displayed a single, well-circumscribed, cystic mass protruding beyond the surface of the pancreas; the rest of the pancreas was normal. Intraoperatively, the cyst was readily apparent once the lesser sac was entered and the surface of the pancreas exposed; the cyst was located at the head (3 cases), neck (1 case), body (6 cases), and tail (9 cases). Surgery was done for all 15 clinical cases and included local excision of the cyst with a thin rim of attached, underlying pancreas (6 cases), or distal pancreatectomy with (4 cases) or without (3 cases) splenectomy. Follow-up information, available in 7 cases, showed that all symptoms disappeared and the patients were alive and well up to 6 years after surgery.
This rare cyst of the pancreas has a uniform and characteristic clinicopathologic profile, enabling easy and accurate diagnosis. Although the histogenesis of lymphoepithelial cysts is not known, they are benign and can be cured by local excision.
胰腺淋巴上皮囊肿是一种罕见但独特的囊性病变，内衬成熟的角化鳞状上皮，周围有淋巴组织。
为了更深入地了解这一实体，我们描述了5例胰腺淋巴上皮囊肿（其中2例之前曾有简要描述），并将它们与文献中的类似病例进行比较，共计19例。
男女比例为16:3；患者年龄在32至73岁之间（平均51岁，中位数51岁）。4例患者（21%）在尸检时偶然发现淋巴上皮囊肿，另外4例患者（21%）在评估无关疾病时发现。在其余11例患者中，囊肿与腹痛相关的有9例（占所有患者的47%），恶心/呕吐3例（16%），腹泻1例（5%），非特异性全身症状6例（32%）（一些患者有不止一种相关症状）。16例患者进行了计算机断层扫描，无论有无超声检查，均显示单个、边界清晰的囊性肿块突出于胰腺表面；胰腺其余部分正常。术中，一旦进入小网膜囊并暴露胰腺表面，囊肿很容易被发现；囊肿位于胰头（3例）、胰颈（1例）、胰体（6例）和胰尾（9例）。15例临床病例均进行了手术，包括囊肿局部切除并带有一小圈附着的胰腺组织（6例），或胰体尾切除术（4例，其中3例同时行脾切除术，1例未行脾切除术）。7例患者有随访信息，显示所有症状消失，患者术后存活且状况良好，最长达6年。
这种罕见的胰腺囊肿具有一致且典型的临床病理特征，便于轻松准确诊断。尽管淋巴上皮囊肿的组织发生尚不清楚，但它们是良性的，可通过局部切除治愈。
